Invitrogen

Ubiquilin 2 Monoclonal Antibody (3B8A10)

Ubiquilin 2 Antibody in Immunocytochemistry (ICC/IF)

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Ubiquilin 2 Antibody (35-4400) in ICC/IF

Immunofluorescence analysis of Dsk2 Monoclonal Antibody (3B8A10) was performed using 70% confluent log phase SH-SY5Y cells treated with 1 uM Nocodazole for 12 h. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Dsk2 (3B8A10) Mouse Monoclonal Antibody at 2 µg/... View More

Ubiquilin 2 Antibody in Western Blot (WB)

Ubiquilin 2 Antibody in Western Blot, Immunoprecipitation (WB, IP)

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产品信息

35-4400

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

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免疫细胞化学 (ICC/IF)

2 µg/mL

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酶联免疫吸附实验 (ELISA)

Assay-dependent

免疫沉淀 (IP)

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产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

3B8A10

抗原

Recombinant protein corresponding to the C-terminal region of the human ubiquilin protein

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

0.1% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2533204

靶标信息

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

The identification of high-preforming antibodies for Ubiquilin-2 for use in Western Blot, immunoprecipitation, and immunofluorescence.

F1000Research

McDowell I,Ayoubi R,Fotouhi M,Southern K,McPherson PS,Laflamme C

35-4400 was used in Immunocytochemistry to select the most appropriate antibody for their specific needs.

Wed Jun 28 00:00:00 UTC 2023

The identification of high-preforming antibodies for Ubiquilin-2 for use in Western Blot, immunoprecipitation, and immunofluorescence.

F1000Research

McDowell I,Ayoubi R,Fotouhi M,Southern K,McPherson PS,Laflamme C

35-4400 was used in Immunocytochemistry to select the most appropriate antibody for their specific needs.

Wed Jun 28 00:00:00 UTC 2023

The identification of high-preforming antibodies for Ubiquilin-2 for use in Western Blot, immunoprecipitation, and immunofluorescence.

F1000Research

McDowell I,Ayoubi R,Fotouhi M,Southern K,McPherson PS,Laflamme C

35-4400 was used in Immunocytochemistry to select the most appropriate antibody for their specific needs.

Wed Jun 28 00:00:00 UTC 2023

The identification of high-preforming antibodies for Ubiquilin-2 for use in Western Blot, immunoprecipitation, and immunofluorescence.

F1000Research

McDowell I,Ayoubi R,Fotouhi M,Southern K,McPherson PS,Laflamme C

35-4400 was used in Immunocytochemistry to select the most appropriate antibody for their specific needs.

Wed Jun 28 00:00:00 UTC 2023

Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation.

Traffic (Copenhagen, Denmark)

Viswanathan J,Haapasalo A,Böttcher C,Miettinen R,Kurkinen KM,Lu A,Thomas A,Maynard CJ,Romano D,Hyman BT,Berezovska O,Bertram L,Soininen H,Dantuma NP,Tanzi RE,Hiltunen M

Tue Mar 01 00:00:00 UTC 2011

Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation.

Traffic (Copenhagen, Denmark)

Viswanathan J,Haapasalo A,Böttcher C,Miettinen R,Kurkinen KM,Lu A,Thomas A,Maynard CJ,Romano D,Hyman BT,Berezovska O,Bertram L,Soininen H,Dantuma NP,Tanzi RE,Hiltunen M

Tue Mar 01 00:00:00 UTC 2011

生物信息学

蛋白别名: Chap1; DSK2 homolog; Nedd4 binding protein 4; PLIC-2; Protein linking IAP with cytoskeleton 2; Ubiquilin-2; Ubiquitin-like product Chap1/Dsk2

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基因别名: ALS15; CHAP1; DSK2; HRIHFB2157; N4BP4; PLIC2; UBQLN2

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UniProt ID: (Human) Q9UHD9

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Entrez Gene ID: (Human) 29978

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功能

protein binding

参与通路

autophagy regulation of macroautophagy ER-associated ubiquitin-dependent protein catabolic process negative regulation of clathrin-mediated endocytosis positive regulation of ER-associated ubiquitin-dependent protein catabolic process negative regulation of G-protein coupled receptor internalization regulation of autophagosome assembly