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Invitrogen
Ubiquitin C Polyclonal Antibody
Product Details
PA5-76144
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide of human Poly-Ubiquitin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2719871
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: polyubiquitin C; Polyubiquitin-C
Gene Aliases: 2700054O04Rik; AI194771; HMG20; Rps27a; TI-225; Uba52; Ubb; UBC
UniProt ID: (Human) P0CG48, (Mouse) Q29120, (Rat) Q63429
Entrez Gene ID: (Human) 7316, (Mouse) 22190, (Rat) 50522
ubiquitin homeostasis
ubiquitin-dependent protein catabolic process
G2/M transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
activation of MAPK activity
protein polyubiquitination
nucleotide-excision repair, DNA damage recognition
nucleotide-excision repair, DNA duplex unwinding
stimulatory C-type lectin receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
glycogen biosynthetic process
transcription-coupled nucleotide-excision repair
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 5'-to lesion
nucleotide-excision repair, DNA gap filling
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
transforming growth factor beta receptor signaling pathway
Notch signaling pathway
I-kappaB kinase/NF-kappaB signaling
JNK cascade
fibroblast growth factor receptor signaling pathway
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
Wnt signaling pathway
endosomal transport
macroautophagy
viral life cycle
virion assembly
translesion synthesis
negative regulation of transforming growth factor beta receptor signaling pathway
anaphase-promoting complex-dependent catabolic process
regulation of type I interferon production
negative regulation of type I interferon production
tumor necrosis factor-mediated signaling pathway
nucleotide-excision repair, DNA incision
ion transmembrane transport
TRIF-dependent toll-like receptor signaling pathway
interstrand cross-link repair
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
ERBB2 signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
error-prone translesion synthesis
DNA damage response, detection of DNA damage
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of mRNA stability
cellular protein metabolic process
innate immune response
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
stress-activated MAPK cascade
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
Wnt signaling pathway, planar cell polarity pathway
regulation of transcription from RNA polymerase II promoter in response to hypoxia
nucleotide-binding oligomerization domain containing signaling pathway
global genome nucleotide-excision repair
error-free translesion synthesis
intracellular transport of virus
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
regulation of signal transduction by p53 class mediator
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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