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Ustekinumab Antibody (MA5-41792) in SDS-PAGE
SDS-PAGE analysis of the recombinant Human IL12B protein expressed in CHO cells using a Ustekinumab biosimilar monoclonal antibody (Product # MA5-41792). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
产品信息
MA5-41792
产品规格
种属反应
All,
Human
宿主/亚型
Human
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Human IL12B
偶联物
形式
Liquid
浓度
0.83 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2910935
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
靶标信息
Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. 2It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. 2It is a targeted biologic disease-modifying anti-rheumatic pharmaceutical (bDMARDs) that is used in the management of various inflammatory conditions that involve the activation of IL-12 and IL-23 signaling pathways. Interleukin (IL)-12 and IL-23 are heterodimeric cytokines that evoke immune and inflammatory responses, such as natural killer cell activation and CD4+ T-cell differentiation and activation. The role of IL-12 and IL-23 were implicated in a variety of chronic inflammatory conditions, such as psoriasis and inflammatory bowel diseases. They modulate lymphocyte function, including T-helper (Th) 1 and Th17 cell subsets, 2as CD4+ T cells can differentiate into T-helper (Th) effector lineages based on the environment. Th cells can further activate the downstream pro-inflammatory mediators and transcription factors such as TNFalpha and IFNgamma that drive innate and adaptive immunity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CNTO 1275; Stelara; TT-20
