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V-ATPase H Antibody (PA5-22134) in ICC/IF
V-ATPase H Polyclonal Antibody detects ATP6V1H protein at cytoplasm by immunofluorescent analysis. Sample: DIV10 rat hippocampal neuron cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: ATP6V1H stained by V-ATPase H Polyclonal Antibody (Product # PA5-22134) diluted at 1:500. Red: Tau, a marker, stained by Tau antibody [GT287] diluted at 1:500.
产品信息
PA5-22134
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 169 and 444 of ATP6V1H (Uniprot ID#Q9UI12)
偶联物
形式
Liquid
浓度
0.76 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_11153525
产品详细信息
Recommended positive controls: 293T, A431, H1299, HeLa, Raji, mouse brain.
Predicted reactivity: Mouse (100%), Zebrafish (91%), Xenopus laevis (94%), Pig (99%), Chicken (96%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H; NBP1; Nef-binding protein 1; Protein VMA13 homolog; V-ATPase 50/57 kDa subunits; V-ATPase H subunit; V-ATPase subunit H; V-type proton ATPase subunit H; vacuolar ATP synthase subunit H; vacuolar ATPase subunit H; vacuolar proton pump H subunit; Vacuolar proton pump subunit H; Vacuolar proton pump subunit SFD
基因别名: 0710001F19Rik; ATP6V1H; AU022349; CGI-11; MSTP042; NBP1; SFD; SFDalpha; SFDbeta; VMA13
UniProt ID: (Human) Q9UI12, (Mouse) Q8BVE3
Entrez Gene ID: (Human) 51606, (Mouse) 108664
endocytosis
vacuolar acidification
insulin receptor signaling pathway
ATP hydrolysis coupled proton transport
viral process
regulation of macroautophagy
transferrin transport
ion transmembrane transport
regulation of defense response to virus by virus
regulation of catalytic activity
phagosome acidification
transport
ion transport
proton transport
