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产品信息
H00081839-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
VANGL1 (NP_620409.1, 1 a.a. approximately 524 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MDTESTYSGY SYYSSHSKKS HRQGERTRER HKSPRNKDGR GSEKSVTIQP PTGEPLLGND STRTEEVQDD NWGETTTAIT GTSEHSISQE DIARISKDME DSVGLDCKRY LGLTVASFLG LLVFLTPIAF ILLPPILWRD ELEPCGTICE GLFISMAFKL LILLIGTWAL FFRKRRADMP RVFVFRALLL VLIFLFVVSY WLFYGVRILD SRDRNYQGIV QYAVSLVDAL LFIHYLAIVL LELRQLQPMF TLQVVRSTDG ESRFYSLGHL SIQRAALVVL ENYYKDFTIY NPNLLTASKF RAAKHMAGLK VYNVDGPSNN ATGQSRAMIA AAARRRDSSH NELYYEEAEH ERRVKKRKAR LVVAVEEAFI HIQRLQAEEQ QKAPGEVMDP REAAQAIFPS MARALQKYLR ITRQQNYHSM ESILQHLAFC ITNGMTPKAF LERYLSAGPT LQYDKDRWLS TQWRLVSDEA VTNGLRDGIV FVLKCLDFSL VVNVKKIPFI ILSEEFIDPK SHKFVLRLQS ETSV
靶标信息
Vang-like 1 protein is a novel human homologue of Drosophila Van Gogh/Strabismus. The Vang-like 1 gene consists of at least 7 exons, and encodes a protein with four transmembrane domains and the C-terminal Ser/Thr-X-Val motif. Studies shows that the expression of the protein is significantly up-regulated in gastric cancer cell lines MKN28, MKN74, pancreatic cancer cell lines BxPC-3, PSN-1 and Hs766T. The protein may serve as an effector mediating the intestinal trefoil factor (ITF) healing response of the intestinal mucosa. The protein also serves as a diagnostic marker for hepatocellular carcinoma as well as a potential molecular target for development of novel therapeutic drugs. The pathological role of the protein has been identified in neural tube defects (NTD). Human Vang-like 1 gene maps to chromosome 1p11-p13.1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: KAI1 C-terminal interacting tetraspanin; Loop-tail protein 2 homolog; LPP2; Strabismus 2; Van Gogh-like protein 1; vang-like 1 (van gogh, Drosophila); Vang-like protein 1
基因别名: KITENIN; LPP2; STB2; STBM2; VANGL1
UniProt ID: (Human) Q8TAA9
Entrez Gene ID: (Human) 81839
