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VANGL1 Antibody (MA5-24592) in ICC/IF
Immunofluorescence staining of VANGL1 in A-431 cells using the VANGL1 Monoclonal Antibody (CL0241) (Product # MA5-24592), showing specific staining in the plasma membrane in green. Microtubule- and nuclear probes are visualized in red and blue, respectively (where available).
产品信息
MA5-24592
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
CL0241
抗原
Recombinant protein corresponding to Human VANGL1
偶联物
形式
Liquid
浓度
0.7 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2637207
产品详细信息
Immunogen sequence: DTESTYSGYS YYSSHSKKSH RQGERTRERH KSPRNKDGRG SEKSVTIQPP TGEPLLGNDS TRTEEVQDDN WGETTTAITG TSEHSISQED IARISKDMED SVGLDCKRY
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
靶标信息
Vang-like 1 protein is a novel human homologue of Drosophila Van Gogh/Strabismus. The Vang-like 1 gene consists of at least 7 exons, and encodes a protein with four transmembrane domains and the C-terminal Ser/Thr-X-Val motif. Studies shows that the expression of the protein is significantly up-regulated in gastric cancer cell lines MKN28, MKN74, pancreatic cancer cell lines BxPC-3, PSN-1 and Hs766T. The protein may serve as an effector mediating the intestinal trefoil factor (ITF) healing response of the intestinal mucosa. The protein also serves as a diagnostic marker for hepatocellular carcinoma as well as a potential molecular target for development of novel therapeutic drugs. The pathological role of the protein has been identified in neural tube defects (NTD). Human Vang-like 1 gene maps to chromosome 1p11-p13.1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: KAI1 C-terminal interacting tetraspanin; Loop-tail protein 2 homolog; LPP2; Strabismus 2; Van Gogh-like protein 1; vang-like 1 (van gogh, Drosophila); Vang-like protein 1
基因别名: KITENIN; LPP2; STB2; STBM2; VANGL1
UniProt ID: (Human) Q8TAA9
Entrez Gene ID: (Human) 81839
