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产品信息
MA5-17050
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
Not Applicable
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
3D5C7
抗原
Purified recombinant fragment of human CDH5 (amino acids: 29-223 ) expressed in E. Coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2538522
产品详细信息
MA5-17050 targets CDH5 in FACS, indirect ELISA, and WB applications and shows reactivity with Human and Rat samples.
The MA5-17050 immunogen is purified recombinant fragment of human CDH5 (amino acids: 29-223 ) expressed in E. Coli.
MA5-17050 detects CDH5 which has a predicted molecular weight of approximately 87.5kDa.
靶标信息
VE-cadherin is a member of the cadherin superfamily that is located in a six-cadherin cluster in a region on the long arm of chromosome 16 and is involved in loss of heterozygosity events in breast and prostate cancer. VE-cadherin protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, VE-cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but the full length sequence of VE-cadherin has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 7B4 antigen; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); Cadherin-5; CD144; cd144 antigen; endothelial-specific cadherin; Vascular endothelial cadherin; VE-cadherin
基因别名: 7B4; CD144; CDH5
UniProt ID: (Human) P33151
Entrez Gene ID: (Human) 1003, (Rat) 307618
blood vessel maturation
cell-cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules
transforming growth factor beta receptor signaling pathway
negative regulation of cell proliferation
single organismal cell-cell adhesion
adherens junction organization
positive regulation of establishment of endothelial barrier
regulation of establishment of cell polarity
