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Invitrogen
VEGF Receptor 2 Recombinant Rabbit Monoclonal Antibody (093)
产品信息
MA5-30949
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
093
抗原
Recombinant Mouse VEGFR2/Flk-1/CD309/KDR protein (Met1-Glu762)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2786618
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Mouse VEGFR2/Flk-1/CD309/KDR.
靶标信息
KDR (FLK1, VEGFR2) is a type III receptor tyrosine kinase. It binds vascular endothelial growth factor with high affinity in vitro, and is expressed early in development by endothelial cell precursors. FLK1 (VEGF Receptor 2) encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of FLK1 (VEGF Receptor 2) are implicated in infantile capillary hemangiomas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD309; CD309 antigen; Fetal liver kinase 1; FLK-1; Kinase NYK; Protein-tyrosine kinase receptor flk-1; sCD309; soluble CD309; soluble vascular endothelial growth factor receptor 2; soluble VEGFR 2; Vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; VEGF R2; VEGF receptor-2; VEGFR-2
基因别名: 6130401C07; Flk-1; Flk1; Kdr; Krd-1; Ly73; sVEGFR-2; VEGFR-2; VEGFR2
UniProt ID: (Mouse) P35918
Entrez Gene ID: (Mouse) 16542
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
vascular endothelial growth factor-activated receptor activity
integrin binding
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
growth factor binding
vascular endothelial growth factor binding
transmembrane signal receptor
angiogenesis
ovarian follicle development
vasculogenesis
response to hypoxia
positive regulation of protein phosphorylation
regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
lymph vessel development
cell migration involved in sprouting angiogenesis
positive regulation of mesenchymal cell proliferation
endocardium development
endothelium development
endochondral bone growth
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cytosolic calcium ion concentration
multicellular organism development
positive regulation of cell proliferation
regulation of cell shape
male gonad development
positive regulation of endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase signaling
phosphorylation
cell migration
peptidyl-tyrosine phosphorylation
hemopoiesis
cell differentiation
lung development
positive regulation of cell migration
positive regulation of BMP signaling pathway
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of TOR signaling
embryonic hemopoiesis
calcium-mediated signaling using intracellular calcium source
cellular response to vascular endothelial growth factor stimulus
peptidyl-tyrosine autophosphorylation
vascular endothelial growth factor signaling pathway
response to drug
negative regulation of apoptotic process
surfactant homeostasis
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
cell fate commitment
endothelial cell differentiation
regulation of endothelial cell differentiation
positive regulation of angiogenesis
positive regulation of vasodilation
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
positive regulation of long-term neuronal synaptic plasticity
lung alveolus development
cell maturation
branching morphogenesis of an epithelial tube
neuron projection morphogenesis
positive regulation of epithelial cell proliferation
positive regulation of calcium-mediated signaling
positive regulation of positive chemotaxis
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of focal adhesion assembly
calcium ion homeostasis
blood vessel endothelial cell differentiation
positive regulation of ERK1 and ERK2 cascade
regulation of hematopoietic progenitor cell differentiation
negative regulation of endothelial cell apoptotic process
positive regulation of vasculogenesis
