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产品信息
PA1-37712
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from C-terminus of human Flt-4 protein
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.6, with 1% BSA
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2213117
产品详细信息
This antibody is predicted to react with canine, porcine and rat based on sequence homology.
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is placenta or breast carcinoma.
靶标信息
Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: FLT-4; FMS-like tyrosine kinase 4; fms-related tyrosine kinase 4; soluble VEGFR 3; sVEGFR 3; Tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; VEGF R3; VEGFR-3
基因别名: FLT-4; FLT4; FLT41; LMPH1A; PCL; VEGFR-3; VEGFR3
UniProt ID: (Human) P35916, (Rat) Q91ZT1
Entrez Gene ID: (Human) 2324, (Rat) 114110
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
vasculature development
lymph vessel development
lymphangiogenesis
sprouting angiogenesis
positive regulation of cell proliferation
positive regulation of vascular endothelial growth factor production
positive regulation of endothelial cell migration
peptidyl-tyrosine phosphorylation
positive regulation of cell growth
cellular response to vascular endothelial growth factor stimulus
vascular endothelial growth factor signaling pathway
negative regulation of apoptotic process
positive regulation of MAPK cascade
positive regulation of JNK cascade
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
blood vessel morphogenesis
regulation of blood vessel remodeling
positive regulation of ERK1 and ERK2 cascade
positive regulation of protein kinase C signaling
transmembrane receptor protein tyrosine kinase signaling pathway
