NeoBiotechnologies

VLDL-Receptor (Very Low Density Lipoprotein Receptor) Recombinant Mouse Monoclonal Antibody (rVLDLR/1337)

VLDL-Receptor (Very Low Density Lipoprotein Receptor) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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VLDL-Receptor (Very Low Density Lipoprotein Receptor) Antibody (7436-MSM3-P1) in IHC (P)

Formalin-fixed, paraffin-embedded human pancreas stained with VLDL-Receptor Recombinant Mouse Monoclonal Antibody (rVLDLR/1337). Inset: PBS instead of primary antibody; secondary only negative control.

VLDL-Receptor (Very Low Density Lipoprotein Receptor) Antibody in Immunoelectrophoresis (IE)

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产品信息

7436-MSM3-P1

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

免疫电泳 (IE)

Assay-dependent

产品规格

种属反应

Human, Rat

宿主/亚型

Mouse / IgG1, kappa

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

rVLDLR/1337

抗原

Recombinant human VLDLR fragment from c-terminal

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A/G

保存液

PBS with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Antibody is stable for 24 months.

Positive Control: HeLaor U-251 cells.Human pancreas, cerebellum, heart or skeletal muscle. Cellular Localization: Cytoplasmic

Specificity Comments: VLDLR (very low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDL receptor, LRP, megalin, VLDLR and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. VLDLR associates with RAP (receptor associated protein) during receptor folding, and RAP facilitates the secretion of the extracellular region of VLDLR. VLDLR is thought to mediate the interaction of extracellular Reelin and cytosolic mDab1 (mammalian disabled protein), which activates a tyrosine kinase. This pathway regulates the migration of neurons along the radial glial fiber network during brain development.

靶标信息

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。