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VNN1 Antibody (PA5-119500) in IHC (P)
Immunohistochemistry analysis of VNN1 in paraffin-embedded Human Stomach tissue. Samples were incubated with polyclonal antibody (Product # PA5-119500) at a dilution of 10 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 2 µg/mL.
产品信息
PA5-119500
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein Vanin 1. The antigen corresponds to amino acid range 389-497 of the target protein.
偶联物
形式
Liquid
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2903998
靶标信息
Hematopoietic precursor cells migrate to the thymus, where they differentiate into mature T lymphocytes. GPI-anchored vanin-1 protein regulates the late adhesion steps of thymus homing of bone marrow precursor cells. Vanin-1 is ubiquitously expressed as a pantetheinase enzyme and catalyzes the hydrolysis of pantetheine for vitamin B5 recycling. The hydrolytic activity of vanin-1 generates the potent antioxidant cysteamine as a metabolite. As a membrane bound pantetheinase, vanin-1 provides the main source of cysteamine under normal physiological conditions. In mice, vanin-1 is expressed specifically in male Sertoli cells of the developing testis, where it aids in cell migration.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Pantetheinase; Pantetheine hydrolase; Tiff66; Vanin-1; Vanin1; vannin 1; Vascular non-inflammatory molecule 1
基因别名: HDLCQ8; Tiff66; VNN1
UniProt ID: (Human) O95497
Entrez Gene ID: (Human) 8876
acute inflammatory response
chronic inflammatory response
biotin metabolic process
nitrogen compound metabolic process
movement of cell or subcellular component
inflammatory response
response to oxidative stress
central nervous system development
pantothenate metabolic process
single organismal cell-cell adhesion
positive regulation of T cell differentiation in thymus
innate immune response
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
