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VPS11 Antibody (PA5-106449) in ICC/IF
Immunofluorescent analysis of VPS11 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and VPS11 polyclonal antibody (Product # PA5-106449) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-106449
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human VPS11(Accession Q9H270), corresponding to amino acid residues F269-K319.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2854120
产品详细信息
Antibody detects endogenous levels of total VPS11.
靶标信息
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hVPS11; RING finger protein 108; vacuolar protein sorting 11 homolog; Vacuolar protein sorting-associated protein 11 homolog; VPS11 CORVET/HOPS core subunit
基因别名: 1200011A11Rik; END1; HLD12; hVPS11; PEP5; PP3476; RNF108; VPS11
UniProt ID: (Human) Q9H270, (Mouse) Q91W86
Entrez Gene ID: (Human) 55823, (Mouse) 71732, (Rat) 315600
intracellular protein transport
vesicle docking involved in exocytosis
autophagy
endosome organization
lysosome organization
endosome to lysosome transport
regulation of protein stability
endosomal vesicle fusion
regulation of SNARE complex assembly
regulation of organelle assembly
positive regulation of cellular protein catabolic process
positive regulation of protein targeting to mitochondrion
positive regulation of early endosome to late endosome transport
transport
protein transport
vesicle-mediated transport
toxin transport
