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VPS28 Antibody (MA5-37876) in IHC (P)
Immunohistochemistry analysis of VPS28 in paraffin-embedded human lung cancer. Samples were incubated with VPS28 Monoclonal antibody (Product # MA5-37876) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
产品信息
MA5-37876
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC2399
抗原
A synthetic peptide corresponding to a sequence within amino acids 122-221 of human VPS28 (Q9UK41)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2897796
产品详细信息
Positive Samples: THP-1, Mouse lung, Mouse brain, Mouse kidney, Rat lung, Rat brain, Rat kidney
Immunogen sequence: KGNLNRCIAD VVSLFITVMD KLRLEIRAMD EIQPDLRELM ETMHRMSHLP PDFEGRQTVS QWLQTLSGMS ASDELDDSQV RQMLFDLESA YNAFNRFLHA
靶标信息
This gene encodes a protein involved in endosomal sorting of cell surface receptors via a multivesicular body/late endosome pathway. The encoded protein is one of the three subunits of the ESCRT-I complex (endosomal complexes required for transport) involved in the sorting of ubiquitinated proteins. The two other subunits of ESCRT-I are vesicular protein sorting 23, also known as tumor susceptibility gene 101 (TSG101), and vesicular protein sorting 37. Two alternative transcripts encoding different isoforms have been described. Additional alternative transcripts may exist but the proteins encoded by these transcripts have not been verified experimentally.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Caspase-activated DNase inhibitor that interacts with ASK1; CIIA; ESCRT-I complex subunit VPS28; H-Vps28; MGC60323; vacuolar protein sorting 28 homolog; vacuolar protein sorting 28-like protein; Vacuolar protein sorting-associated protein 28 homolog; yeast class E protein Vps28p homolog
基因别名: 1110014J03Rik; CIIA; D730005C08Rik; VPS28
UniProt ID: (Human) Q9UK41, (Mouse) Q9D1C8
Entrez Gene ID: (Human) 51160, (Mouse) 66914, (Rat) 300052
autophagy
endosomal transport
viral life cycle
negative regulation of protein ubiquitination
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
positive regulation of protein catabolic process
intracellular transport of virus
positive regulation of ubiquitin-dependent endocytosis
