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VPS33B Antibody (PA5-97158) in WB
Western blot analysis of VPS33B in extracts of various cell lines. Samples were incubated with VPS33B Polyclonal antibody (Product # PA5-97158) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
产品信息
PA5-97158
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 348-617 of human VPS33B (NP_0611383)
偶联物
形式
Liquid
浓度
1.4 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808960
产品详细信息
Immunogen sequence: CESIMKKKTK QDFQELIKTE HALLEGFNIR ESTSYIEEHI DRQVSPIESL RLMCLLSITE NGLIPKDYRS LKTQYLQSYG PEHLLTFSNL RRAGLLTEQA PGDTLTAVES KVSKLVTDKA AGKITDAFSS LAKRSNFRAI SKKLNLIPRV DGEYDLKVPR DMAYVFGGAY VPLSCRIIEQ VLERRSWQGL DEVVRLLNCS DFAFTDMTKE DKASSESLRL ILVVFLGGCT FSEISALRFL GREKGYRFIF LTTAVTNSAR LMEAMSEVKA; Positive Samples: A-549, MCF7, DU145; Cellular Location: Cytoplasmic side, Cytoplasmic vesicle, Early endosome, Late endosome membrane, Lysosome membrane, Peripheral membrane protein, Recycling endosome, clathrin-coated vesicle
靶标信息
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ14848; hVPS33B; vacuolar protein sorting 33 homolog B; vacuolar protein sorting 33-like protein B; Vacuolar protein sorting-associated protein 33B
基因别名: VPS33B
UniProt ID: (Human) Q9H267, (Mouse) P59016
Entrez Gene ID: (Human) 26276, (Mouse) 233405
vesicle docking involved in exocytosis
endosome organization
endosome to lysosome transport
protein transport
vesicle-mediated transport
melanosome localization
lysosome localization
megakaryocyte development
membrane fusion
platelet alpha granule organization
regulation of platelet aggregation
autophagosome maturation
transport
