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产品信息
PA5-30654
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 1 and 311 of Human VPS35
偶联物
形式
Liquid
浓度
0.64 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2548128
产品详细信息
Recommended positive controls: HCT116, NIH-3T3, JC.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (94%), Xenopus laevis (97%), Chicken (98%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp434E1211; DKFZp434P1672; FLJ10752; FLJ13588; FLJ20388; hVPS35; Maternal embryonic message 3; Maternal-embryonic 3; vacuolar protein sorting 35 homolog; Vacuolar protein sorting-associated protein 35; Vesicle protein sorting 35
基因别名: AI647796; MEM3; PARK17; TCCCTA00141; VPS35
UniProt ID: (Human) Q96QK1, (Mouse) Q9EQH3
Entrez Gene ID: (Human) 55737, (Rat) 25479, (Mouse) 65114
intracellular protein transport
Wnt signaling pathway
regulation of macroautophagy
regulation of protein stability
retrograde transport, endosome to Golgi
transcytosis
positive regulation of Wnt protein secretion
positive regulation of canonical Wnt signaling pathway
negative regulation of late endosome to lysosome transport
retrograde transport, endosome to plasma membrane
vacuolar protein processing
transport
protein transport
