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产品信息
PA5-23508
产品规格
种属反应
Bovine,
Dog,
Chicken,
Horse,
Hamster,
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Portion of amino acids 165-215 of human viperin
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2541008
靶标信息
Viperin is a 43kDa protein which is one of several hundred interferon inducible viral proteins. Elevated expression of viperin is induced by LPS and poly I:C through TLR dependent signaling pathways. Sendai virus mediated viperin expression is induced independently of TLR signaling pathways through RLRs - RIG-I and MAVs (Severa, 2006). Viperin has been shown to play an important role in interferon mediated anti-viral activity in a Hepatitis C virus model system (Helbig, 2011). Viperin is induced in lymphoid cells and dendritic cells (DCs) and highly induced in neutrophils and macrophages during acute LCMV infection in mice (Hinson, ). Viperin functions as a mediator of viral resistance and as a marker for interferon responsiveness making its detection and mechanism of action through specific antibody probes valuable for further studies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bone-expressed sequence tag 5 protein; Cytomegalovirus-induced gene 5 protein; Inflammatory response gene 6 protein; inflammatory response protein 6; IRG6; radical S-adenosyl methionine domain containing 2; Radical S-adenosyl methionine domain-containing protein 2; RSAD2; rsad2 {ECO:0000250|UniProtKB:Q8WXG1}; S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; SAND; VHSV-induced-like protein; Viperin; viral hemorrhagic septicemia virus (VHSV)-induced gene 1; Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
基因别名: 2510004L01Rik; Best5; cig33; CIG5; CIG6; IRG6; RSAD2; Vig1; viperin
UniProt ID: (Pig) Q9MZU4, (Bovine) Q2HJF9, (Human) Q8WXG1, (Rat) O70600, (Mouse) Q8CBB9
response to virus
positive regulation of toll-like receptor 7 signaling pathway
positive regulation of toll-like receptor 9 signaling pathway
CD4-positive, alpha-beta T cell activation
CD4-positive, alpha-beta T cell differentiation
innate immune response
negative regulation of protein secretion
defense response to virus
positive regulation of T-helper 2 cell cytokine production
ossification
metabolic process
regulation of ossification
negative regulation of viral genome replication
immune system process
type I interferon signaling pathway
