Invitrogen

WAPL Polyclonal Antibody

WAPL Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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WAPL Antibody (PA5-38024) in IHC (P)

Immunohistochemistry of WAPL in rat heart tissue with WAPL Polyclonal Antibody (Product # PA5-38024) at 5 µg/mL.

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产品信息

PA5-38024

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-2 µg/mL

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免疫组化（石蜡） (IHC (P))

5 µg/mL

染色质免疫沉淀实验 (ChIP)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

18 amino acid peptide near the amino terminus of human WAPL

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2554628

产品详细信息

A recommended positive control is A-20 cell lysate.

At least four isoforms of WAPL are known to exist.

靶标信息

Transcriptional repressor which may play a role in development of the central nervous system (CNS).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Loop extrusion mediates physiological Igh locus contraction for RAG scanning.

Nature

Dai HQ,Hu H,Lou J,Ye AY,Ba Z,Zhang X,Zhang Y,Zhao L,Yoon HS,Chapdelaine-Williams AM,Kyritsis N,Chen H,Johnson K,Lin S,Conte A,Casellas R,Lee CS,Alt FW

PA5-38024 was used in Western Blotting and ChIP Assay to find that the expression of wings apart-like protein homologue (WAPL)10, a cohesin-unloading factor, was low in primary progenitor B cells compared with v-Abl-transformed progenitor B cell lines that lacked contraction and RAG scanning of the VH locus.

Mon Feb 01 00:00:00 UTC 2021

Loop extrusion mediates physiological Igh locus contraction for RAG scanning.

Nature

Dai HQ,Hu H,Lou J,Ye AY,Ba Z,Zhang X,Zhang Y,Zhao L,Yoon HS,Chapdelaine-Williams AM,Kyritsis N,Chen H,Johnson K,Lin S,Conte A,Casellas R,Lee CS,Alt FW

Mon Feb 01 00:00:00 UTC 2021

Loop extrusion mediates physiological Igh locus contraction for RAG scanning.

Nature

Dai HQ,Hu H,Lou J,Ye AY,Ba Z,Zhang X,Zhang Y,Zhao L,Yoon HS,Chapdelaine-Williams AM,Kyritsis N,Chen H,Johnson K,Lin S,Conte A,Casellas R,Lee CS,Alt FW

Mon Feb 01 00:00:00 UTC 2021

生物信息学

蛋白别名: DIF-2; Dioxin-inducible factor 2; friend of EBNA2; friend of EBNA2 (Epstein-Barr virus nuclear protein 2); Friend of EBNA2 protein; WAPL cohesin release factor; wings apart-like homolog (Drosophila); Wings apart-like protein homolog

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基因别名: A530089A20Rik; BC037674; DIF-2; FOE; KIAA0261; RGD1308960; WAPAL; WAPL

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UniProt ID: (Human) Q7Z5K2, (Mouse) Q65Z40

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Entrez Gene ID: (Human) 23063, (Rat) 290577, (Mouse) 218914

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功能

protein binding molecular_function

参与通路