Invitrogen

WDR5 Monoclonal Antibody (7B11)

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WDR5 Antibody (MA5-15664) in WB

Western blot analysis of WDR5 using WDR5 monoclonal antibody (Product # MA5-15664) in HeLa (1) cell lysate.

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产品信息

MA5-15664

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

查看4篇已发表文章 4篇已发表文章

酶联免疫吸附实验 (ELISA)

1:10,000

产品规格

种属反应

Human

已发表种属

Human, Pig

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

7B11

抗原

Purified recombinant fragment of human WDR5 expressed in E. Coli.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

Conc. Not Determined

保存液

ascites

内含物

0.03% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_10977947

产品详细信息

MA5-15664 targets WDR5 in indirect ELISA, WB applications and shows reactivity with Human samples.

The MA5-15664 immunogen is purified recombinant fragment of human WDR5 expressed in E. Coli.

MA5-15664 detects WDR5 which has a predicted molecular weight of approximately 36.6kDa.

靶标信息

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Reappraisal of hMLH1 promoter methylation and protein expression status in the serrated neoplasia pathway.

Histopathology

Lee EJ,Chun SM,Kim MJ,Jang SJ,Kim do S,Lee DH,Youk EG

MA515664 was used in immunohistochemistry - paraffin section to examine the methylation and inactivation of hMLH1 in the progression of sessile serrated lesions

Mon Aug 01 00:00:00 UTC 2016

CD109 Mediates Cell Survival in Hepatocellular Carcinoma Cells.

Digestive diseases and sciences

Zong G,Xu Z,Zhang S,Shen Y,Qiu H,Zhu G,He S,Tao T,Chen X

MA515664 was used in immunohistochemistry - paraffin section to investigate the molecular mechanisms that contribute to hepatocellular carcinoma

Mon Aug 01 00:00:00 UTC 2016

Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs.

PloS one

Bähr A,Käser T,Kemter E,Gerner W,Kurome M,Baars W,Herbach N,Witter K,Wünsch A,Talker SC,Kessler B,Nagashima H,Saalmüller A,Schwinzer R,Wolf E,Klymiuk N

MA515664 was used in immunohistochemistry - paraffin section to generate and characterize the immune system of CAG-LEA29Y transgenic pigs

Mon Jul 10 00:00:00 UTC 2017

Low expression of PIDD is associated with cell proliferation and apoptosis in hepatocellular carcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Shi W,Huang W,Chen Y,Zhang S,Xu P,Gu X,Fan H,Xu J,Chen Y,Ni R,Lu C,Zhang X

MA515664 was used in immunohistochemistry - paraffin section to determine the role of p53-induced death domain protein in hepatocellular carcinoma development

Mon Aug 01 00:00:00 UTC 2016

Clonal X-chromosome inactivation suggests that splenic cord capillary hemangioma is a true neoplasm and not a subtype of splenic hamartoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Chiu A,Czader M,Cheng L,Hasserjian RP,Wang M,Bhagavathi S,Hyjek EM,Al-Ahmadie H,Knowles DM,Orazi A

MA5-15664 was used in Immunohistochemistry to show that in spite of considerable morphologic heterogeneity and overlapping features, classical hamartoma and cord capillary hemangioma and myoid angioendothelioma are different in terms of their vascular and stromal composition.

Sat Jan 01 00:00:00 UTC 2011

生物信息学

蛋白别名: BMP2-induced 3-kb gene protein; cilia and flagella associated protein 89; SWD3, Set1c WD40 repeat protein, homolog; WD repeat-containing protein 5

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基因别名: BIG-3; BIG3; CFAP89; SWD3; WDR5

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UniProt ID: (Human) P61964

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Entrez Gene ID: (Human) 11091

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功能

protein binding histone-lysine N-methyltransferase activity methylated histone binding histone methyltransferase activity (H3-K4 specific) histone acetyltransferase activity (H4-K5 specific) histone acetyltransferase activity (H4-K8 specific) histone acetyltransferase activity (H4-K16 specific)

参与通路

skeletal system development transcription, DNA-templated neuron projection development positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter histone H3 acetylation histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K16 acetylation histone H3-K4 methylation