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产品信息
PA5-56848
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2649646
产品详细信息
Immunogen sequence: CKKSGQSYSP SRVLITENDV KEGLQRSHIL YDRAGEEHYN CISALHKSMR GSDQNASLYW LARMLEGGED PLYVARRLVR FAS
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
靶标信息
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.
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生物信息学
蛋白别名: ATPase WRNIP1; FLJ22526; putative helicase RUVBL; RP11-420G6.2; Werner helicase-interacting protein 1; WRNIP1
基因别名: bA420G6.2; WHIP; WRNIP1
UniProt ID: (Human) Q96S55
Entrez Gene ID: (Human) 56897
