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WIPI1 Antibody (PA5-116123) in IHC (P)
Immunohistochemistry analysis of WIPI1 in human colorectal cancer and adjacent normal tissues. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-116123) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
产品信息
PA5-116123
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human WIPI1(Accession Q5MNZ9), corresponding to amino acid residues L247-M297.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900757
产品详细信息
Antibody detects endogenous levels of total WIPI1.
靶标信息
WIPI1 (WD repeat domain, phosphoinositide interacting-1), also known as WIPI1, ATG18 or WIPI49, is thought to play a role in autophagy and may regulate protein trafficking in certain recycling pathways. It contains three WD repeats and has a 7-bladed propeller structure with a conserved motif that facilitates its interaction with other proteins. WIPI1 localizes to cytoplasmic vesicles, endosomes, clathrin-coated vesicles and the trans-Golgi network. It is ubiquitously expressed with highest expression in heart, testis, placenta, pancreas and skeletal muscle. WIPI1 is upregulated in a variety of tumors, suggesting a role in carcinogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Atg18 protein homolog; WD repeat domain phosphoinositide-interacting protein 1; WD40 repeat protein interacting with phosphoinositides of 49 kDa; WD40 repeat protein Interacting with phosphoInositides of 49kDa; WIPI 49 kDa; WIPI-1; WIPI-1 alpha
基因别名: 4930533H01Rik; ATG18; ATG18A; AW411817; D11Ertd498e; RGD1307754; WIPI1; WIPI49
UniProt ID: (Human) Q5MNZ9, (Mouse) Q8R3E3
Entrez Gene ID: (Human) 55062, (Rat) 303630, (Mouse) 52639
