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产品信息
PA5-54425
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2649655
产品详细信息
Immunogen sequence: MKVLHTIRET PPNPAGLCAL SINNDNCYLA YPGSATIGEV QVFDTINLRA ANMIPAHDSP LAALAFDASG TKLATASEKG TVIRVF
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 100%.
靶标信息
WD repeat proteins play a role in many essential biologic functions, regulating the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. WIPI2, also known as ATG18B or ATG21, is a human homolog to yeast ATG18 and contains three WD repeats and has a 7-bladed propeller structure with a conserved motif that facilitates its interaction with other proteins. It is recruited to early autophagosomal structures along with Atg16L and ULK1 and is required for the formation of LC3-positive autophagosomes. Along with the highly related WIPI1, WIPI2 is found at the plasma membrane in addition to autophagosomal membranes.
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生物信息学
蛋白别名: WD repeat domain phosphoinositide-interacting protein 2; WD40 repeat protein interacting with phosphoinositides 2; WIPI-2; WIPI49-like protein 2
基因别名: ATG18B; Atg21; CGI-50; WIPI-2; WIPI2
UniProt ID: (Human) Q9Y4P8
Entrez Gene ID: (Human) 26100
