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产品信息
PA5-45677
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N-terminal of human WNK2 (aa 136-185).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2576378
产品详细信息
Peptide sequence: APAPDGGPRE EAAATVRKED EGAAEAKPEP GRTRRDEPEE EEDDEDDLKA
Sequence homology: Dog: 79%; Guinea Pig: 86%; Horse: 92%; Human: 100%; Mouse: 86%; Rat: 86%
靶标信息
WNK2 is a serine/threonine kinase involved in signal transduction and cellular communication. WNK kinases contain a lysine upstream of the traditional position, within a glycine string. This lysine functions as an anchor and orients ATP through interactions with the alpha and beta phosphoryl groups. The catalytic domains of WNK2, WNK3 and WNK4 are 95% homologous to WNK1. The human WNK1 gene encodes a 2,382 amino acid protein that is primarily expressed in heart, kidney, muscle and distal nephron. The human WNK3 gene encodes a protein that is primarily expressed in brain; the human WNK4 gene encodes a 1,243 amino acid protein that is expressed in kidney. Aberrant function of WNK kinases and their associated signaling pathways are implicated in hypertension, increased renal salt reabsorption and impaired K+ and H+ excretion.
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生物信息学
蛋白别名: Antigen NY-CO-43; mitogen-activated protein kinase kinase kinase; Protein kinase lysine-deficient 2; Protein kinase with no lysine 2; protein kinase, lysine deficient 2; Serine/threonine-protein kinase WNK2; Serologically defined colon cancer antigen 43
基因别名: KIAA1760; NY-CO-43; P/OKcl.13; PRKWNK2; SDCCAG43; WNK2
UniProt ID: (Human) Q9Y3S1
Entrez Gene ID: (Human) 65268
