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Product Details
PA5-95130
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Wnt4 (232-249aa HALKEKFDGATEVEPRRV).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2806935
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: MCF-7 whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein Wnt-4; signal molecule; wingless-related MMTV integration site 4; wingless-type MMTV integration site family member 4; wingless-type MMTV integration site family, member 4
Gene Aliases: SERKAL; UNQ426/PRO864; WNT-4; WNT4
UniProt ID: (Human) P56705, (Rat) Q9QXQ5, (Mouse) P22724
Entrez Gene ID: (Human) 54361, (Rat) 84426, (Mouse) 22417
metanephros development
branching involved in ureteric bud morphogenesis
kidney development
mesonephros development
epithelial to mesenchymal transition
embryonic epithelial tube formation
liver development
androgen biosynthetic process
gamete generation
sex differentiation
male gonad development
female gonad development
cellular response to starvation
negative regulation of gene expression
negative regulation of steroid biosynthetic process
Wnt signaling pathway
protein palmitoylation
regulation of cell-cell adhesion
cell differentiation
neuron differentiation
female sex determination
adrenal gland development
negative regulation of cell migration
positive regulation of bone mineralization
positive regulation of aldosterone biosynthetic process
response to estradiol
positive regulation of collagen biosynthetic process
T cell differentiation in thymus
immature T cell proliferation in thymus
tube morphogenesis
non-canonical Wnt signaling pathway
non-canonical Wnt signaling pathway via MAPK cascade
negative regulation of fibroblast growth factor receptor signaling pathway
hormone metabolic process
cell fate commitment
negative regulation of cell differentiation
positive regulation of osteoblast differentiation
positive regulation of meiotic nuclear division
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
oocyte development
branching morphogenesis of an epithelial tube
anatomical structure development
smooth muscle cell differentiation
positive regulation of stress fiber assembly
positive regulation of focal adhesion assembly
canonical Wnt signaling pathway
somatotropin secreting cell differentiation
thyroid-stimulating hormone-secreting cell differentiation
mesenchymal to epithelial transition
tertiary branching involved in mammary gland duct morphogenesis
kidney morphogenesis
negative regulation of wound healing
mammary gland epithelium development
positive regulation of dermatome development
paramesonephric duct development
negative regulation of testicular blood vessel morphogenesis
cellular response to estradiol stimulus
cellular response to hydrostatic pressure
cellular response to transforming growth factor beta stimulus
nephron development
renal vesicle formation
renal vesicle induction
mesonephric tubule development
metanephric tubule formation
metanephric nephron development
metanephric nephron morphogenesis
establishment of protein localization to plasma membrane
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
negative regulation of male gonad development
positive regulation of cortisol biosynthetic process
negative regulation of testosterone biosynthetic process
negative regulation of apoptotic signaling pathway
positive regulation of GTPase activity
metanephric mesenchymal cell differentiation
signal transduction
cell-cell signaling
multicellular organism development
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