Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-28289
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 20 and 349 of Human WNT7A
偶联物
形式
Liquid
浓度
0.21 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545765
产品详细信息
Recommended positive controls: WNT7A-transfected 293T.
Predicted reactivity: Mouse (100%), Rat (100%), Chicken (96%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. It is expressed in placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family, ultimately leading to the disruption of ß-catenin degradation. Intracellular accumulation of ß-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to induce the expression of numerous genes. Increased Wnt/ß-catenin signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: postaxial hemimelia; Protein Wnt-7a; proto-oncogene Wnt7a protein; wingless-related MMTV integration site 7A; wingless-type MMTV integration site family member 7A; wingless-type MMTV integration site family, member 7A
基因别名: AI849442; px; tw; Wnt-7a; WNT7A
UniProt ID: (Human) O00755, (Mouse) P24383
Entrez Gene ID: (Human) 7476, (Mouse) 22421
embryonic axis specification
cartilage condensation
angiogenesis
chondrocyte differentiation
neurotransmitter secretion
axonogenesis
synapse assembly
sex differentiation
asymmetric protein localization
dorsal/ventral pattern formation
positive regulation of endothelial cell migration
skeletal muscle satellite cell activation
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
Wnt signaling pathway
cerebellar granule cell differentiation
cell proliferation in forebrain
central nervous system vasculogenesis
establishment of cell polarity
regulation of axon diameter
response to estradiol
somatic stem cell population maintenance
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
non-canonical Wnt signaling pathway
Wnt signaling pathway involved in wound healing, spreading of epidermal cells
synaptic vesicle recycling
embryonic digit morphogenesis
negative regulation of apoptotic process
response to estrogen
cell fate commitment
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
somatic stem cell division
stem cell development
negative regulation of neurogenesis
positive regulation of synapse assembly
palate development
positive regulation of epithelial cell proliferation involved in wound healing
oviduct development
canonical Wnt signaling pathway
dendritic spine morphogenesis
uterus morphogenesis
lens fiber cell development
cellular response to transforming growth factor beta stimulus
positive regulation of canonical Wnt signaling pathway
positive regulation of protein localization to synapse
excitatory synapse assembly
positive regulation of excitatory synapse assembly
positive regulation of excitatory postsynaptic potential
signal transduction
cell-cell signaling
multicellular organism development
positive regulation of cell proliferation
organ morphogenesis
positive regulation of gene expression
embryonic limb morphogenesis
forelimb morphogenesis
hindlimb morphogenesis
regulation of cell proliferation
skin morphogenesis
reproductive structure development
skeletal system morphogenesis
regulation of axonogenesis
synapse organization
cartilage development
uterus development
limb development
positive regulation of receptor activity
