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WNT8A Antibody (PA5-103481) in ICC/IF
Immunofluorescent analysis of WNT8A in 3T3 cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and WNT8A polyclonal antibody (Product # PA5-103481) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-103481
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human WNT8A(Accession Q9H1J5), corresponding to amino acid residues N164-Q214.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2852817
产品详细信息
Antibody detects endogenous levels of total WNT8A.
靶标信息
WNT8A, part of the WNT gene family, consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Protein Wnt-8a; Protein Wnt-8d; Stimulated by retinoic acid gene 11 protein; wingless-related MMTV integration site 8A; wingless-related MMTV integration site 8D; wingless-type MMTV integration site family member 8A; wingless-type MMTV integration site family, member 8A; wnt-8; WNT8d
基因别名: Stra11; Wnt-8A; Wnt-8D; WNT8A; WNT8D
UniProt ID: (Human) Q9H1J5, (Mouse) Q64527
Entrez Gene ID: (Human) 7478, (Mouse) 20890
neural crest cell fate commitment
Wnt signaling pathway
neuron differentiation
response to retinoic acid
regulation of transcription involved in anterior/posterior axis specification
canonical Wnt signaling pathway involved in neural crest cell differentiation
palate development
canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
beta-catenin destruction complex disassembly
cell morphogenesis
regionalization
multicellular organism development
endoderm development
polarity specification of anterior/posterior axis
polarity specification of proximal/distal axis
regulation of protein localization
cell fate commitment
establishment of organ orientation
