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产品信息
PA5-45620
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the C-terminal of human WWC1 (aa 793-842).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2606824
产品详细信息
Peptide sequence: SRELKPVGVM APASGPASTD AVSALLEQTA VELEKRQEGR SSTQTLEDSW
Sequence homology: Cow: 93%; Dog: 79%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 79%; Rat: 100%
靶标信息
WWC1 (Protein KIBRA) is a probable regulator of the Hippo/SWH signaling pathway. This pathway plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. WWC1, along with NF2, can synergistically induce the phosphorylation of LATS1 and LATS2. It acts as a transcriptional coactivator of ESR1 - which plays an essential role in DYNLL1-mediated ESR1 transactivation. WWC1 also functions as a regulatior of collagen-stimulated activation of the ERK/MAPK cascade.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ10865; FLJ23369; HBeAg-binding protein 3; KIBRA; Kidney and brain protein; Protein KIBRA; protein phosphatase 1, regulatory subunit 168; protein WWC1; WW domain-containing protein 1; WW, C2 and coiled-coil domain containing 1
基因别名: HBEBP3; HBEBP36; KIAA0869; KIBRA; MEMRYQTL; PPP1R168; WWC1
UniProt ID: (Human) Q8IX03
Entrez Gene ID: (Human) 23286
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
cell migration
establishment of cell polarity
regulation of intracellular transport
hippo signaling
regulation of hippo signaling
negative regulation of hippo signaling
positive regulation of MAPK cascade
negative regulation of organ growth
