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产品信息
PA5-72829
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
WWC1 antibody for an 18 amino acid peptide near the amino terminus of human WWC1. The immunogen is within amino acids 60 - 110 of WWC1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2718683
靶标信息
WWC1 (Protein KIBRA) is a probable regulator of the Hippo/SWH signaling pathway. This pathway plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. WWC1, along with NF2, can synergistically induce the phosphorylation of LATS1 and LATS2. It acts as a transcriptional coactivator of ESR1 - which plays an essential role in DYNLL1-mediated ESR1 transactivation. WWC1 also functions as a regulatior of collagen-stimulated activation of the ERK/MAPK cascade.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ10865; FLJ23369; HBeAg-binding protein 3; KIBRA; Kidney and brain protein; Protein KIBRA; protein phosphatase 1, regulatory subunit 168; protein WWC1; WW and C2 domain containing 1; WW domain-containing protein 1; WW, C2 and coiled-coil domain containing 1
基因别名: AA408228; AU017197; BC037006; HBEBP3; HBEBP36; KIAA0869; KIBRA; MEMRYQTL; mKIAA0869; PPP1R168; RGD1308329; WWC1
UniProt ID: (Human) Q8IX03, (Mouse) Q5SXA9
Entrez Gene ID: (Human) 23286, (Rat) 303039, (Mouse) 211652
negative regulation of transcription from RNA polymerase II promoter
cell migration
regulation of hippo signaling
negative regulation of hippo signaling
positive regulation of MAPK cascade
negative regulation of organ growth
transcription, DNA-templated
establishment of cell polarity
regulation of intracellular transport
hippo signaling
regulation of transcription, DNA-templated
