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产品信息
PA5-65423
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2662641
产品详细信息
Immunogen sequence: KLCTVSYGKVK LVLKHNRYFV ESCHPDVIQH LLQDPVIREC RLRNSEGEAT ELITETFTSK SAISKTAESS GGPSTSRVTD PQGKSDIPMD LFDFYEQMDK DEEEEE
Highest antigen sequence identity to the following orthologs - mouse 90%, rat 90%.
靶标信息
The human XPB DNA helicase is a subunit of the DNA repair/basal transcription factor TFIIH, and is involved in early steps of the nucleotide excision repair (NER) pathway. Two distinct clinical phenotypes, xeroderma pigmentosum associated with Cockayne's syndrome (XP/CS) and trichothiodystrophy (TTD), can be due to mutations in the XPB gene.
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生物信息学
蛋白别名: Basic transcription factor 2 89 kDa subunit; BTF2 p89; DNA 3'-5' helicase/translocase XPB; DNA excision repair protein ERCC-3; DNA repair helicase; DNA repair protein complementing XP-B cells; excision repair cross-complementation group 3; excision repair cross-complementing rodent repair deficiency, complementation group 3; General transcription and DNA repair factor IIH helicase/translocase subunit XPB; TFIIH 89 kDa subunit; TFIIH basal transcription factor complex 89 kDa subunit; TFIIH p89; TFIIH subunit XPB; Xeroderma pigmentosum group B-complementing protein; xeroderma pigmentosum, complementation group B
基因别名: BTF2; ERCC3; GTF2H; RAD25; TFIIH; TTD2; XPB; XPBC
UniProt ID: (Human) P19447
Entrez Gene ID: (Human) 2071
DNA binding
damaged DNA binding
ATP-dependent DNA helicase activity
helicase activity
protein kinase activity
protein binding
ATP binding
GTP binding
protein C-terminus binding
DNA-dependent ATPase activity
transcription factor binding
RNA polymerase II carboxy-terminal domain kinase activity
ATPase activity
dATP binding
peptide binding
3'-5' DNA helicase activity
protein N-terminus binding
DNA metabolism protein
DNA helicase
nucleic acid metabolism protein
nucleotide-excision repair, DNA duplex unwinding
response to hypoxia
DNA topological change
DNA repair
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
7-methylguanosine mRNA capping
protein phosphorylation
apoptotic process
response to oxidative stress
protein localization
response to UV
UV protection
viral process
nucleotide-excision repair, DNA incision
hair cell differentiation
positive regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
global genome nucleotide-excision repair
regulation of mitotic cell cycle phase transition
