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XPC Antibody (A301-122A) in WB
Detection of human XPC by western blot and immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-XPC antibody (Product # A301-122A) used for WB at 0.04 µg/mL (A) and 0.1 µg/mL (B) and used for IP at 3 µg/mg lysate. XPC was also immunoprecipitated by rabbit anti-XPC antibody A301-121A, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 seconds (A) and 30 seconds (B).
产品信息
A301-122A
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 890 and 940 of Human xeroderma pigmentosum, complementation group C.
偶联物
形式
Liquid
浓度
0.20 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Dog, Orangutan, Monkey, Gorilla and Chimpanzee
靶标信息
This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA repair protein complementing XP-C cells; mutant xeroderma pigmentosum group C; NER; p125; Xeroderma pigmentosum group C-complementing protein; xeroderma pigmentosum, complementation group C
基因别名: p125; RAD4; XP3; XPC; XPCC
UniProt ID: (Human) Q01831
Entrez Gene ID: (Human) 7508
nucleotide-excision repair, DNA damage recognition
nucleotide-excision repair, DNA duplex unwinding
DNA repair
nucleotide-excision repair
nucleotide-excision repair, preincision complex assembly
mismatch repair
response to UV-B
response to auditory stimulus
protein sumoylation
intra-S DNA damage checkpoint
response to drug
global genome nucleotide-excision repair
UV-damage excision repair
regulation of mitotic cell cycle phase transition
