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产品信息
PA5-102437
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ERCC5(Accession P28715), corresponding to amino acid residues E140-S190.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2851842
产品详细信息
Antibody detects endogenous levels of total ERCC5.
靶标信息
Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: COFS 3; DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells; DNA repair protein complementing XP-G cells homolog; ERCC 5; ERCM 2; excision repair cross-complementation group 5; excision repair cross-complementing rodent repair deficiency, complementation group 5; OTTHUMP00000064902; RP11-484I6.5; Xe; xeroderma pigmentosum; Xeroderma pigmentosum group G-complementing protein; xeroderma pigmentosum group G-complementing protein homolog; xeroderma pigmentosum, complementation group G; XPG; XPG-complementing protein
基因别名: COFS3; ERCC5; ERCC5-201; ERCM2; UVDR; XPG; XPGC
UniProt ID: (Human) P28715
Entrez Gene ID: (Human) 2073, (Mouse) 22592, (Rat) 301382
bubble DNA binding
double-stranded DNA binding
single-stranded DNA binding
endodeoxyribonuclease activity
protein binding
protein homodimerization activity
metal ion binding
protein N-terminus binding
DNA binding
catalytic activity
nuclease activity
endonuclease activity
hydrolase activity
hydrolase activity, acting on ester bonds
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
molecular_function
DNA metabolism protein
transcription-coupled nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
response to UV
UV protection
response to UV-C
nucleotide-excision repair, DNA incision
negative regulation of apoptotic process
DNA repair
nucleotide-excision repair
cellular response to DNA damage stimulus
determination of adult lifespan
multicellular organism growth
DNA catabolic process, endonucleolytic
biological_process
metabolic process
nucleic acid phosphodiester bond hydrolysis
