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产品信息
200-901-MG5
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Chicken
/ IgY
分类
Polyclonal
类型
Antibody
抗原
Anti-XRCC1 antibody was prepared from eggs of chickens laid after repeated immunizations with a synthetic peptide corresponding to a N-Terminal portion of human XRCC1 conjugated to Keyhole Limpet Hemocyanin (KLH).
偶联物
形式
Liquid
浓度
0.93 mg/mL
纯化类型
selective precipitation
保存液
PBS, pH 7
内含物
0.01% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This purified antibody is directed against human XRCC1. This product is an IgY fraction antibody purified from monospecific chicken egg yolks by a multi-step process which includes selective precipitation and salt fractionation followed by extensive dialysis against the buffer stated above.
靶标信息
XRCC1 (X-ray cross complementing factor-1) is involved in DNA base excision repair. XRCC1 is a 70 kDa protein that has been shown to be physically associated with other DNA repair enzymes, including poly (ADP-ribose) polymerase (PARP), DNA Ligase III and DNA polymerase beta. XRCC1 contains a BRCT domain (for BRCA1 carboxyl terminus) which was originally found in the tumor suppressor protein BRCA1. Recently, the BRCT domain has been shown to mediate the protein-protein interaction of XRCC1 and DNA ligase III-alpha.
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生物信息学
蛋白别名: DNA repair protein XRCC1; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross-complementing protein 1
基因别名: RCC; Xrcc-1; XRCC1
UniProt ID: (Human) P18887, (Mouse) Q60596
Entrez Gene ID: (Human) 7515, (Mouse) 22594
single strand break repair
double-strand break repair via homologous recombination
response to hypoxia
transcription-coupled nucleotide-excision repair
base-excision repair
base-excision repair, DNA ligation
nucleotide-excision repair, DNA gap filling
response to organic substance
response to drug
DNA repair
cellular response to DNA damage stimulus
hippocampus development
