Product References
APTX acts in DNA double-strand break repair in a manner distinct from XRCC4.
Journal of radiation research
Imamura R,Saito M,Shimada M,Kobayashi J,Ishiai M,Matsumoto Y
Published figure using XRCC1 monoclonal antibody (Product # MA5-13412) in Western Blot
Thu May 25 00:00:00 UTC 2023
The Novel Role of hnRNP UL1 in Human Cell Nucleoli.
International journal of biological sciences
Cichocka M,Karlik A,Plewka P,Gawade K,Stępień A,Świergiel P,Gadgil A,Raczyńska KD
Published figure using XRCC1 monoclonal antibody (Product # MA5-13412) in Western Blot
Mon Aug 22 00:00:00 UTC 2022
Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription.
Proceedings of the National Academy of Sciences of the United States of America
Sengupta S,Wang H,Yang C,Szczesny B,Hegde ML,Mitra S
MA5-13412 was used in Immunoprecipitation to show induction of oxidized bases and single-strand breaks (SSBs), but not direct double-strand breaks (DSBs), in the genome during gene activation by ligands of the nuclear receptor superfamily.
Tue Sep 08 00:00:00 UTC 2020
Linker region is required for efficient nuclear localization of polynucleotide kinase phosphatase.
PloS one
Tsukada K,Matsumoto Y,Shimada M
MA5-13412 was used in Western Blotting to investigate the mechanisms regulating nuclear localisation and subnuclear distribution of polynucleotide kinase phosphatase.
Thu Nov 05 00:00:00 UTC 2020
Linker region is required for efficient nuclear localization of polynucleotide kinase phosphatase.
PloS one
Tsukada K,Matsumoto Y,Shimada M
MA5-13412 was used in Western Blotting to investigate the mechanisms regulating nuclear localisation and subnuclear distribution of polynucleotide kinase phosphatase.
Thu Nov 05 00:00:00 UTC 2020
Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer.
PloS one
Lee KJ,Piett CG,Andrews JF,Mann E,Nagel ZD,Gassman NR
MA5-13412 was used in Western Blot to evaluate the potential of XRCC1 as an indicator of BER defects in TNBC, we examined XRCC1 expression in the TCGA database and its expression and localization in triple negative breast cancers cell lines.
Mon Mar 09 00:00:00 UTC 2020
Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer.
PloS one
Lee KJ,Piett CG,Andrews JF,Mann E,Nagel ZD,Gassman NR
MA5-13412 was used in Western Blot to evaluate the potential of XRCC1 as an indicator of BER defects in TNBC, we examined XRCC1 expression in the TCGA database and its expression and localization in triple negative breast cancers cell lines.
Mon Mar 09 00:00:00 UTC 2020
Base excision repair defects invoke hypersensitivity to PARP inhibition.
Molecular cancer research : MCR
Horton JK,Stefanick DF,Prasad R,Gassman NR,Kedar PS,Wilson SH
MA5-13412 was used in western blot to
Fri Aug 01 00:00:00 UTC 2014
Clinicopathological and functional significance of XRCC1 expression in ovarian cancer.
International journal of cancer
Abdel-Fatah T,Sultana R,Abbotts R,Hawkes C,Seedhouse C,Chan S,Madhusudan S
MA5-13412 was used in immunohistochemistry to study the function and predictive value of XRCC1 in ovarian cancer
Sat Jun 15 00:00:00 UTC 2013
Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses.
DNA repair
Horton JK,Stefanick DF,Gassman NR,Williams JG,Gabel SA,Cuneo MJ,Prasad R,Kedar PS,Derose EF,Hou EW,London RE,Wilson SH
MA5-13412 was used in western blot to study the effect of cellular XRCC1 oxidation on PARP-mediated DNA damage responses
Sun Sep 01 00:00:00 UTC 2013
Interaction between DNA Polymerase β and BRCA1.
PloS one
Masaoka A,Gassman NR,Horton JK,Kedar PS,Witt KL,Hobbs CA,Kissling GE,Tano K,Asagoshi K,Wilson SH
MA5-13412 was used in western blot to study the functional significance of the DNA polymerase-beta interaction with BRCA1
Wed Oct 11 00:00:00 UTC 2017
The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries.
Journal of signal transduction
Watt HL,Rachid Z,Jean-Claude BJ
MA5-13412 was used in immunocytochemistry and western blot to study the concept of divergent targeting through the activation and inhibition of receptors as a novel chemotherapeutic strategy
Thu Aug 23 00:00:00 UTC 2012
The prognostic significance of ERCC1, BRCA1, XRCC1, and betaIII-tubulin expression in patients with non-small cell lung cancer treated by platinum- and taxane-based neoadjuvant chemotherapy and surgical resection.
Lung cancer (Amsterdam, Netherlands)
Kang CH,Jang BG,Kim DW,Chung DH,Kim YT,Jheon S,Sung SW,Kim JH
MA5-13412 was used in immunohistochemistry to investigate the usefulness of specific gene expression in non-small cell lung cancer treatment prognosis
Tue Jun 01 00:00:00 UTC 2010
Subcellular distribution of a fluorescence-labeled combi-molecule designed to block epidermal growth factor receptor tyrosine kinase and damage DNA with a green fluorescent species.
Molecular cancer therapeutics
Todorova MI,Larroque AL,Dauphin-Pierre S,Fang YQ,Jean-Claude BJ
MA5-13412 was used in western blot to study the subcellular distribution of a mixed EGFR-DNA targeting molecule utilizing a green labelled DNA-damaging moiety and a blue-labelled EGFR inhibitor
Thu Apr 01 00:00:00 UTC 2010
XRCC1 protects against the lethality of induced oxidative DNA damage in nondividing neural cells.
Nucleic acids research
Kulkarni A,McNeill DR,Gleichmann M,Mattson MP,Wilson DM
MA5-13412 was used in immunocytochemistry to study the role of XRCC1 in protecting against the lethality of induced oxidative DNA damage in nondividing neural cells
Mon Sep 01 00:00:00 UTC 2008
Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair.
The EMBO journal
Chou WC,Wang HC,Wong FH,Ding SL,Wu PE,Shieh SY,Shen CY
MA5-13412 was used in western blot to study the role of Chk2-dependent XRCC1 phosphorylation in the DNA damage response
Wed Dec 03 00:00:00 UTC 2008
Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair.
The EMBO journal
Chou WC,Wang HC,Wong FH,Ding SL,Wu PE,Shieh SY,Shen CY
MA5-13412 was used in western blot to study the role of Chk2-dependent XRCC1 phosphorylation in the DNA damage response
Wed Dec 03 00:00:00 UTC 2008
Tamoxifen accelerates proteasomal degradation of O6-methylguanine DNA methyltransferase in human cancer cells.
International journal of cancer
Kuo CC,Liu JF,Shiah HS,Ma LC,Chang JY
MA5-13412 was used in western blot to study the role of tamoxifen in increasing proteasomal degradation of MGMT in human cancer cells
Thu Nov 15 00:00:00 UTC 2007
Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks.
The Journal of biological chemistry
Bekker-Jensen S,Fugger K,Danielsen JR,Gromova I,Sehested M,Celis J,Bartek J,Lukas J,Mailand N
MA5-13412 was used in western blot to study the role of human Xip1 in regulating cellular responses to DNA strand breaks
Fri Jul 06 00:00:00 UTC 2007
An intronic polymorphism associated with increased XRCC1 expression, reduced apoptosis and familial breast cancer.
Breast cancer research and treatment
Bu D,Tomlinson G,Lewis CM,Zhang C,Kildebeck E,Euhus DM
MA5-13412 was used in western blot to investigate the relation between XRCC1 expression and apoptosis in breast cancer cell lines
Sun Oct 01 00:00:00 UTC 2006
Replication-dependent and -independent responses of RAD18 to DNA damage in human cells.
The Journal of biological chemistry
Nakajima S,Lan L,Kanno S,Usami N,Kobayashi K,Mori M,Shiomi T,Yasui A
MA5-13412 was used in immunocytochemistry to study the role of RAD18 in the responses to DNA damage in human cells
Fri Nov 10 00:00:00 UTC 2006
XRCC1 and DNA polymerase beta interaction contributes to cellular alkylating-agent resistance and single-strand break repair.
Journal of cellular biochemistry
Wong HK,Wilson DM
MA5-13412 was used in western blot to study the role of XRCC1 and DNA polymerase beta in cellular alkylating-agent resistance and single-strand break repair
Fri Jul 01 00:00:00 UTC 2005
In situ analysis of repair processes for oxidative DNA damage in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America
Lan L,Nakajima S,Oohata Y,Takao M,Okano S,Masutani M,Wilson SH,Yasui A
MA5-13412 was used in immunocytochemistry to study the mammalian repair mechanism for oxidation-induced DNA damage
Tue Sep 21 00:00:00 UTC 2004
Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.
The Journal of biological chemistry
Audebert M,Salles B,Calsou P
MA5-13412 was used in western blot to study an alternative pathway for the repair of DNA double-strand breaks that involves poly(ADP-ribose) polymerase-1 and a XRCC1-DNA ligase III complex
Fri Dec 31 00:00:00 UTC 2004
Oxidative DNA damage and repair in experimental atherosclerosis are reversed by dietary lipid lowering.
Circulation research
Martinet W,Knaapen MW,De Meyer GR,Herman AG,Kockx MM
MA5-13412 was used in western blot to study the effects of dietary lipid levels on DNA damage and DNA repair pathways in experimentally induced atherosclerotic plaques
Fri Apr 13 00:00:00 UTC 2001
