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XRCC3 Antibody (PA5-76005) in ICC/IF
Knockdown of DNA repair protein XRCC3 was achieved by transfecting PC-3 cells with DNA repair protein XRCC3 specific siRNA (Silencer® select Product # s14946, s14948). Immunofluorescence analysis was performed on untransfected PC-3 cells (panel a,d), transfected with non-specific scrambled siRNA (panels b,e) and transfected with DNA repair protein XRCC3 specific siRNA (panel c,f). Cells were fixed, permeabilized, and labelled with XRCC3 Polyclonal Antibody (Product # PA5-76005, 1:100 dilution) followed by Goat anti-Rabbit IgG (H+L) Highly ... View More
产品信息
PA5-76005
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length Human XRCC3.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2719733
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA repair protein XRCC3; DNA repair protein XRCC3-like; RAD51 like; X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair cross-complementing protein 3; XRCC 3
基因别名: 4432412E01Rik; AI182522; AW537713; CMM6; XRCC3
UniProt ID: (Human) O43542, (Mouse) Q9CXE6
Entrez Gene ID: (Rat) 102551085, (Human) 7517, (Mouse) 74335
recombinase activity
four-way junction DNA binding
double-stranded DNA binding
single-stranded DNA binding
protein binding
ATP binding
DNA-dependent ATPase activity
crossover junction endodeoxyribonuclease activity
nucleotide binding
DNA binding
DNA metabolism protein
nucleic acid metabolism protein
meiotic DNA recombinase assembly
telomere maintenance via recombination
double-strand break repair via homologous recombination
DNA synthesis involved in DNA repair
strand displacement
DNA repair
DNA recombination
cellular response to DNA damage stimulus
reciprocal meiotic recombination
response to organic substance
response to ionizing radiation
regulation of centrosome duplication
interstrand cross-link repair
strand invasion
resolution of mitotic recombination intermediates
positive regulation of mitotic cell cycle spindle assembly checkpoint
t-circle formation
