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The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Peptide O-xylosyltransferase 1; protein xylosyltransferase 2; UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase; XT-II; Xylosyltransferase 2; Xylosyltransferase II
基因别名: PXYLT2; SOS; UNQ3058/PRO9878; XT-II; XT2; xylT-II; XYLT2
UniProt ID: (Human) Q9H1B5
Entrez Gene ID: (Human) 64132