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产品信息
H00010009-M02
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3A8
抗原
ZBTB33 (AAH42753, 564 a.a. approximately 673 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.26 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunogen sequence: QFMSSHIKSV HSQDPSGDSK LYRLHPCRSL QIRQYAYLSD RSSTIPAMKD DGIGYKVDTG KEPPVGTTTS TQNKPMTWED IFIQQENDSI FKQNVTDGST EFEFIIPESY
靶标信息
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha 2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
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生物信息学
蛋白别名: kaiso transcription factor; RP23-322E15.9; Transcriptional regulator Kaiso; WUGSC:H_DJ525N14.1; Zinc finger and BTB domain-containing protein 33
基因别名: KAISO; ZBTB33; ZNF-kaiso; ZNF348
UniProt ID: (Human) Q86T24
Entrez Gene ID: (Human) 10009
