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ZCCHC11 Antibody (PA5-100054) in ICC/IF
Immunofluorescent analysis of ZCCHC11 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and ZCCHC11 polyclonal antibody (Product # PA5-100054) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-100054
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ZCCHC11(Accession Q5TAX3), corresponding to amino acid residues I1125-L1175.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2815584
产品详细信息
Antibody detects endogenous levels of total ZCCHC11.
靶标信息
WDR77 is a component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: PAP associated domain containing 3; RP23-406B13.1; Terminal uridylyltransferase 4; TUTase 4; Zinc finger CCHC domain-containing protein 11; zinc finger, CCHC domain containing 11
基因别名: 6030404K05Rik; 9230115F04Rik; KIAA0191; mKIAA0191; PAPD3; PPAPD3; TUT4; ZCCHC11
UniProt ID: (Human) Q5TAX3, (Mouse) B2RX14
Entrez Gene ID: (Human) 23318, (Rat) 313481, (Mouse) 230594
miRNA metabolic process
miRNA catabolic process
stem cell population maintenance
pre-miRNA processing
RNA 3'-end processing
histone mRNA catabolic process
cytokine production
regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
positive regulation of interleukin-6 production
interleukin-6-mediated signaling pathway
gene silencing by RNA
