Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-68795
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the N terminal region of mouse ZFPM1
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2689301
产品详细信息
This target displays homology in the following species: Mouse: 100%; Rat: 85%
靶标信息
ZFPM1 is a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM1 is an essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. ZFPM1 may be involved in regulation of some genes in gonads. ZFPM1 may also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: FOG-1; Friend of GATA 1; Friend of GATA protein 1; Friend of GATA-1; Zinc finger protein multitype 1; Zinc finger protein ZFPM1
基因别名: FOG; Fog1; Zfpm1
UniProt ID: (Mouse) O35615
Entrez Gene ID: (Mouse) 22761
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
RNA polymerase II activating transcription factor binding
nucleic acid binding
DNA binding
transcription corepressor activity
protein binding
transcription factor binding
metal ion binding
transcription cofactor
negative regulation of transcription from RNA polymerase II promoter
outflow tract morphogenesis
atrioventricular valve morphogenesis
mitral valve formation
tricuspid valve formation
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
heart development
regulation of definitive erythrocyte differentiation
erythrocyte differentiation
megakaryocyte differentiation
platelet formation
granulocyte differentiation
negative regulation of protein binding
regulation of chemokine production
embryonic hemopoiesis
megakaryocyte development
positive regulation of interferon-gamma biosynthetic process
negative regulation of interleukin-4 biosynthetic process
negative regulation of fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
homeostasis of number of cells
cardiac muscle tissue morphogenesis
definitive erythrocyte differentiation
primitive erythrocyte differentiation
negative regulation of mast cell differentiation
ventricular septum morphogenesis
atrial septum morphogenesis
transcriptional activation by promoter-enhancer looping
