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ZFPM2 Antibody (PA5-103342) in ICC/IF
Immunocytochemistry analysis of ZFPM2 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with ZFPM2 polyclonal antibody (Product # PA5-103342) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-103342
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ZFPM2(Accession Q8WW38), corresponding to amino acid residues G995-N1045.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2852687
产品详细信息
Antibody detects endogenous levels of total FOG2.
靶标信息
The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FOG-2; Friend of GATA 2; Friend of GATA protein 2; friend of GATA-1 2; friend of GATA-2; Friend of GATA2; mFOG-2; transcription factor GATA4, modulator of; Zinc finger protein 89B; Zinc finger protein multitype 2; Zinc finger protein ZFPM2; zinc finger protein, multitype 2
基因别名: B330005D23Rik; DIH3; FOG-2; FOG2; hFOG-2; SRXY9; ZC2HC11B; ZFPM2; ZNF89B
UniProt ID: (Human) Q8WW38, (Mouse) Q8CCH7
Entrez Gene ID: (Human) 23414, (Mouse) 22762
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
RNA polymerase II transcription coactivator activity
DNA binding
transcription corepressor activity
protein binding
transcription factor binding
zinc ion binding
nucleic acid binding
metal ion binding
transcription cofactor
negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
in utero embryonic development
outflow tract septum morphogenesis
right ventricular cardiac muscle tissue morphogenesis
transcription, DNA-templated
gonadal mesoderm development
blood coagulation
lung development
negative regulation of fat cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
ventricular septum morphogenesis
negative regulation of cell death
positive regulation of male gonad development
negative regulation of female gonad development
outflow tract morphogenesis
atrioventricular valve morphogenesis
mitral valve formation
tricuspid valve formation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
heart development
positive regulation of transcription, DNA-templated
cardiac muscle tissue development
cardiac muscle tissue morphogenesis
vasculogenesis involved in coronary vascular morphogenesis
