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产品信息
MA5-22803
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
3G4-2B11
抗原
ZFYVE19 (AAH15738.1, 1 a.a. ~ 396 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2606037
产品详细信息
Peptide Sequence: MESRCYGCAV KFTLFKKEYG CKNCGRAFCS GCLSFSAAVP RTGNTQQKVC KQCHEVLTRG SSANASKWSP PQNYKKRVAA LEAKQKPSTS QSQGLTRQDQ MIAERLARLR QENKPKLVPS QAEIEARLAA LKDERQGSIP STQEMEARLA ALQGRVLPSQ TPQPAHHTPD TRTQAQQTQD LLTQLAAEVA IDESWKGGGP AASLQNDLNQ GGPGSTNSKR QANWSLEEEK SRLLAEAALE LREENTRQER ILALAKRLAM LRGQDPERVT LQDYRLPDSD DDEDEETAIQ RVLQQLTEEA ALDEASGFNI PAEQASRPWT QPRGAEPEAQ DVDPRPEAEE EELPWCCICN EDATLRCAGC DGDLFCARCF REGHDAFELK EHQTSAYSPP RAGQEH
靶标信息
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Abscission/NoCut checkpoint regulator; ANCHR; MLL partner containing FYVE domain; Zinc finger FYVE domain-containing protein 19; zinc finger, FYVE domain containing 19
基因别名: ANCHR; MPFYVE; ZFYVE19
UniProt ID: (Human) Q96K21
Entrez Gene ID: (Human) 84936
