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ZIC2 Antibody (PA5-23446) in WB
Western blot analysis of ZIC2 in HepG2 cell lysate using 1) pre-bleed, and 2) this antibody. Samples were incubated in ZIC2 polyclonal antibody (Product # PA5-23446) followed by a goat anti-rabbit Ig HRP secondary antibody. PicoTect ECL substrate solution was used for this test.
产品信息
PA5-23446
产品规格
种属反应
Bovine,
Dog,
Chicken,
Horse,
Human,
Mouse,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acid 350 to 400 of human ZIC2
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2540946
靶标信息
ZIC2 (zinc finger protein of the cerebellum 2) is a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. In mouse, knockout of Zic1 leads to aplasia of cerebellum and skeletal abnormalities. Mutation in Zic2 and Zic3 in mouse and/or human cause holoprosencephaly and heterotaxis, respectively. Holoprosencephaly is the most common structural anomaly of the human brain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cerebellum zinc finger protein 2; GENA 29; kumba; odd-paired homolog; Zic family member 2 (odd-paired homolog, Drosophila); Zinc finger protein of the cerebellum 2; Zinc finger protein ZIC 2
基因别名: BOS_12680; HPE5; Ku; ZIC2
UniProt ID: (Human) O95409
Entrez Gene ID: (Bovine) 514433, (Dog) 485533, (Human) 7546, (Mouse) 22772
DNA binding
transcription factor activity, sequence-specific DNA binding
chromatin DNA binding
metal ion binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
nucleic acid binding
protein binding
neural tube closure
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
nervous system development
central nervous system development
visual perception
cell differentiation
retinal ganglion cell axon guidance
cilium organization
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
developmental pigmentation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
brain development
