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产品信息
PA5-21064
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
An 18 amino acid peptide near the center of human ZIP10.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11157030
产品详细信息
A suggested positive control is human spleen tissue lysate.
PA5-21064 can be used with blocking peptide PEP-1178.
靶标信息
ZIP10, also known as Slc39A10, is a widely expressed zinc transporter with nine transmembrane domains. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP10 mRNA was found to be significantly decreased in the intestines and kidneys of hypothyroid rats and increased in those of hyperthyroid rats, indicating that ZIP10 is positively regulated by thyroid hormones. ZIP10 mRNA was also found to be upregulated in invasive and metastatic breast cancer and cell lines, suggesting that ZIP10 could serve as a possible marker for the metastatic phenotype and possibly a target for novel treatment strategies. At least three isoforms of ZIP10 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: solute carrier family 39 (metal ion transporter), member 10; solute carrier family 39 (zinc transporter), member 10; Solute carrier family 39 member 10; Zinc transporter ZIP10; ZIP-10; Zrt- and Irt-like protein 10
基因别名: 2900042E17Rik; 5430433I10; KIAA1265; LZT-Hs2; mKIAA1265; SLC39A10; ZIP10
UniProt ID: (Human) Q9ULF5, (Mouse) Q6P5F6
Entrez Gene ID: (Human) 57181, (Mouse) 227059, (Rat) 363229
negative regulation of B cell apoptotic process
cellular zinc ion homeostasis
positive regulation of B cell proliferation
positive regulation of B cell receptor signaling pathway
zinc II ion transmembrane import
positive regulation of protein tyrosine phosphatase activity
transport
ion transport
zinc II ion transport
biological_process
metal ion transport
transmembrane transport
