Invitrogen

ZIPK Polyclonal Antibody

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ZIPK Antibody (PA5-17118) in WB

Western blot was performed using Anti-ZIPK Polyclonal Antibody(Product # PA5-17118) and a 52kDa band corresponding to ZIPK was observed in Mouse Kidney and Rat kidney in comparison to Mouse Spleen, Rat Spleen, Mouse Liver and Rat Liver which is reported to be low. Tissue extracts (30 µg lysate) of Mouse Kidney (Lane 1), Rat Kidney (Lane 2), Mouse Spleen (Lane 3), Rat Spleen (Lane 4), Mouse Liver (Lane 5) and Rat Liver (Lane 6) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). Resolved proteins were then t... View More

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ZIPK Antibody — Antibody specificity was demonstrated by detection of differential basal expression of the target across tissues owing to their inherent genetic constitution. Relative expression of ZIPK was observed in Mouse Kidney and Rat kidney in comparison to Mouse Spleen, Rat Spleen, Mouse Liver and Rat Liver. using Anti-ZIPK Polyclonal Antibody (Product # PA5-17118) in Western Blot. {RE}

产品信息

PA5-17118

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

产品规格

种属反应

Human, Mouse, Non-human primate, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to residues at the carboxyl terminus of human DAPK3/ZIPK

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

Antigen affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

no preservative

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_10987464

产品详细信息

It is not recommended to aliquot this antibody.

靶标信息

DAPK3 is a serine/threonine kinase which is functionally linked to cell motility, smooth muscle contractility and cell death processes. DAPK3 is encoded by ZIPK and is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DAP kinase 3; DAP-like kinase; DAP3K; death-associated kinase 3; Death-associated like kinase; Death-associated protein kinase 3; Dlk; MYPT1 kinase; ZIP kinase; ZIP kinase isoform; ZIP-kinase; Zipper-interacting protein kinase

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基因别名: DAPK3; Dapkl; DLK; ZIP; ZIPK

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UniProt ID: (Human) O43293, (Rat) O88764, (Mouse) O54784

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Entrez Gene ID: (Human) 1613, (Rat) 64391, (Mouse) 13144

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