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产品信息
PA5-27700
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 1 and 172 of Human DAP kinase 3
偶联物
形式
Liquid
浓度
0.61 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545176
产品详细信息
Recommended positive controls: A549.
Predicted reactivity: Mouse (96%), Rat (96%), Xenopus laevis (87%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
DAPK3 is a serine/threonine kinase which is functionally linked to cell motility, smooth muscle contractility and cell death processes. DAPK3 is encoded by ZIPK and is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DAP kinase 3; DAP-like kinase; DAP3K; death-associated kinase 3; Death-associated like kinase; Death-associated protein kinase 3; Dlk; MYPT1 kinase; ZIP kinase; ZIP kinase isoform; ZIP-kinase; Zipper-interacting protein kinase
基因别名: DAPK3; Dapkl; DLK; ZIP; ZIPK
UniProt ID: (Human) O43293, (Rat) O88764, (Mouse) O54784
Entrez Gene ID: (Human) 1613, (Rat) 64391, (Mouse) 13144
protein serine/threonine kinase activity
protein binding
ATP binding
protein C-terminus binding
cAMP response element binding protein binding
Rho GTPase binding
identical protein binding
protein homodimerization activity
leucine zipper domain binding
calmodulin-dependent protein kinase activity
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
cytokinesis
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
apoptotic process
regulation of smooth muscle contraction
regulation of mitotic nuclear division
regulation of mitotic cell cycle
regulation of cell shape
regulation of autophagy
covalent chromatin modification
negative regulation of translation
neuron differentiation
positive regulation of cell migration
intracellular signal transduction
regulation of apoptotic process
positive regulation of apoptotic process
regulation of myosin II filament organization
protein autophosphorylation
regulation of focal adhesion assembly
cellular response to interferon-gamma
positive regulation of canonical Wnt signaling pathway
apoptotic signaling pathway
regulation of cell motility
regulation of actin cytoskeleton reorganization
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
chromatin modification
phosphorylation
