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产品信息
PA5-50742
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues near the N terminal of human zinc finger, MIZ-type containing 1
偶联物
形式
Liquid
浓度
2.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2636194
产品详细信息
The antibody detects endogenous levels of total ZMIZ1 protein.
靶标信息
Retinoic acid plays a critical role in development, cellular growth, and differentiation and induces the expression of a variety of genes. RAI17 expression is induced by retinoic acid and is predominantly expressed in heart, brain and ovaries. Within brain, highest expression is in amygdala. The deduced 1,067-amino acid protein contains an MSX-interacting zinc finger (MIZ) domain, a nuclear localization signal sequence, and 2 proline-rich regions. A strong intrinsic transactivation domain is identified in the C-terminal proline-rich region. RAI17 expression is detected in various cancer cell lines. RAI17 colocalizes with endogenous androgen receptor (AR) in the nuclei of prostate epithelial cells from human tissue samples. In human prostate cancer cells, RAI17 increases the transcriptional activity of AR. Studies using sumoylation-deficient AR mutants suggest that the increase of AR activity by RAI17 is dependent upon receptor sumoylation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ00092 protein; PIAS-like protein Zimp10; retinoic acid induced 17; Retinoic acid-induced protein 17; RP11-519K18.1; Zinc finger MIZ domain-containing protein 1; zinc finger, MIZ-type containing 1; zinc finger-containing, Miz1, PIAS-like protein on chromosome 10
基因别名: BC065120; E330020C23; ENSMUSG00000072684; Gm10397; hZIMP10; I920194n01; KIAA1224; MIZ; RAI17; TRAFIP10; ZIMP10; ZMIZ1
UniProt ID: (Human) Q9ULJ6, (Mouse) Q6P1E1
Entrez Gene ID: (Human) 57178, (Mouse) 328365
vasculogenesis
in utero embryonic development
heart morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
vitellogenesis
cell aging
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
developmental growth
artery morphogenesis
