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产品信息
PA5-51177
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Fusion protein of human ZNF268
偶联物
形式
Liquid
浓度
0.9 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2636625
产品详细信息
The antibody detects endogenous levels of total ZNF268 protein.
靶标信息
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a krueppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger protein 268 (ZNF268), also known as zinc finger protein 3 or HZF3, is a 947 amino acid protein belonging to the krueppel C2H2-type zinc-finger protein family. ZNF268 contains 24 C2H2-type zinc fingers and one KRAB domain. Localized to the nucleus, ZNF268 is involved in transcriptional regulation and is highly expressed in three to five week old embryos. ZNF268 has been implicated in human leukemia, due to the identification of an alternatively spliced form in leukemia patients. Two named isoforms of ZNF268 exist as a result of alternative splicing events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Zinc finger protein 268; zinc finger protein 3; Zinc finger protein HZF3
基因别名: HZF3; ZNF268
UniProt ID: (Human) Q14587
Entrez Gene ID: (Human) 10795
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of mitotic cell cycle
positive regulation of cell proliferation
negative regulation of cell proliferation
cell differentiation
positive regulation of cell migration
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of cell differentiation
positive regulation of transcription from RNA polymerase II promoter during mitosis
negative regulation of cell cycle arrest
