Product References
CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety.
Cell discovery
Zhu X,Meng J,Han C,Wu Q,Du Y,Qi J,Wei L,Li H,He W,Zhang K,Lu Y
PA5-85256 was used in Immunohistochemistry (PFA) to establish the association between high myopia and anxiety, and implicate the CCL2-mediated inflammatory pathogenesis as an underlying mechanism.
Tue Sep 12 00:00:00 UTC 2023
CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety.
Cell discovery
Zhu X,Meng J,Han C,Wu Q,Du Y,Qi J,Wei L,Li H,He W,Zhang K,Lu Y
PA5-85256 was used in Immunohistochemistry (PFA) to establish the association between high myopia and anxiety, and implicate the CCL2-mediated inflammatory pathogenesis as an underlying mechanism.
Tue Sep 12 00:00:00 UTC 2023
Long Noncoding RNA ENSG00000254693 Promotes Diabetic Kidney Disease via Interacting with HuR.
Journal of diabetes research
Yu Q,Lin J,Ma Q,Li Y,Wang Q,Chen H,Liu Y,Liu B
Published figure using ZO-1 polyclonal antibody (Product # PA5-85256) in Immunocytochemistry
Tue May 03 00:00:00 UTC 2022
Long Noncoding RNA ENSG00000254693 Promotes Diabetic Kidney Disease via Interacting with HuR.
Journal of diabetes research
Yu Q,Lin J,Ma Q,Li Y,Wang Q,Chen H,Liu Y,Liu B
Published figure using ZO-1 polyclonal antibody (Product # PA5-85256) in Immunocytochemistry
Tue May 03 00:00:00 UTC 2022
Injection of amyloid-β to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer's disease.
Journal of neuroinflammation
Qian XH,Liu XL,Chen G,Chen SD,Tang HD
PA5-85256 was used in Immunohistochemistry and Western Blotting to suggest that Aβ in the CNS can induce gut microbiota dysbiosis, alter intestinal structure and accelerate the amyloidogenic pathways, which were related to inhibiting cholinergic anti-inflammatory pathways.
Wed Sep 28 00:00:00 UTC 2022
Injection of amyloid-β to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer's disease.
Journal of neuroinflammation
Qian XH,Liu XL,Chen G,Chen SD,Tang HD
PA5-85256 was used in Immunohistochemistry and Western Blotting to suggest that Aβ in the CNS can induce gut microbiota dysbiosis, alter intestinal structure and accelerate the amyloidogenic pathways, which were related to inhibiting cholinergic anti-inflammatory pathways.
Wed Sep 28 00:00:00 UTC 2022
Injection of amyloid-β to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer's disease.
Journal of neuroinflammation
Qian XH,Liu XL,Chen G,Chen SD,Tang HD
PA5-85256 was used in Immunohistochemistry and Western Blotting to suggest that Aβ in the CNS can induce gut microbiota dysbiosis, alter intestinal structure and accelerate the amyloidogenic pathways, which were related to inhibiting cholinergic anti-inflammatory pathways.
Wed Sep 28 00:00:00 UTC 2022
Injection of amyloid-β to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer's disease.
Journal of neuroinflammation
Qian XH,Liu XL,Chen G,Chen SD,Tang HD
PA5-85256 was used in Immunohistochemistry and Western Blotting to suggest that Aβ in the CNS can induce gut microbiota dysbiosis, alter intestinal structure and accelerate the amyloidogenic pathways, which were related to inhibiting cholinergic anti-inflammatory pathways.
Wed Sep 28 00:00:00 UTC 2022
The Host CYP1A1-Microbiota Metabolic Axis Promotes Gut Barrier Disruption in Methicillin-Resistant Staphylococcus aureus-Induced Abdominal Sepsis.
Frontiers in microbiology
Ma X,Jin H,Chu X,Dai W,Tang W,Zhu J,Wang F,Yang X,Li W,Liu G,Yang X,Liang H
PA5-85256 was used in Immunohistochemistry to reveal the unexpected function of host CYP1A1 in microbiota-mediated cadaverine metabolism, with crucial consequences for dysbacteriosis following MRSA-induced abdominal sepsis, indicating that inhibiting CYP1A1 or blocking cadaverine-histamine H4 receptor signaling could be a potential therapeutic target against abdominal sepsis.
Sat Jul 16 00:00:00 UTC 2022
The Host CYP1A1-Microbiota Metabolic Axis Promotes Gut Barrier Disruption in Methicillin-Resistant Staphylococcus aureus-Induced Abdominal Sepsis.
Frontiers in microbiology
Ma X,Jin H,Chu X,Dai W,Tang W,Zhu J,Wang F,Yang X,Li W,Liu G,Yang X,Liang H
PA5-85256 was used in Immunohistochemistry to reveal the unexpected function of host CYP1A1 in microbiota-mediated cadaverine metabolism, with crucial consequences for dysbacteriosis following MRSA-induced abdominal sepsis, indicating that inhibiting CYP1A1 or blocking cadaverine-histamine H4 receptor signaling could be a potential therapeutic target against abdominal sepsis.
Sat Jul 16 00:00:00 UTC 2022
Transmissible Gastroenteritis Virus Infection Promotes the Self-Renewal of Porcine Intestinal Stem Cells via Wnt/β-Catenin Pathway.
Journal of virology
Yang N,Zhang Y,Fu Y,Li Y,Yang S,Chen J,Liu G
PA5-85256 was used in Immunohistochemistry to investigate he mechanism behind the epithelium regeneration upon ransmissible gastroenteritis virus infection.
Wed Sep 28 00:00:00 UTC 2022
Overexpression of Mitochondrial Ferritin Enhances Blood-Brain Barrier Integrity Following Ischemic Stroke in Mice by Maintaining Iron Homeostasis in Endothelial Cells.
Antioxidants (Basel, Switzerland)
Wang P,Ren Q,Shi M,Liu Y,Bai H,Chang YZ
PA5-85256 was used in Western Blotting to identify a previously unexplored effect for FtMt in the BBB and provide evidence that iron-mediated oxidative stress in BMVECs is an early cause of BMVECs damage and BBB breakdown in ischemic stroke.
Sun Jun 26 00:00:00 UTC 2022
Overexpression of Mitochondrial Ferritin Enhances Blood-Brain Barrier Integrity Following Ischemic Stroke in Mice by Maintaining Iron Homeostasis in Endothelial Cells.
Antioxidants (Basel, Switzerland)
Wang P,Ren Q,Shi M,Liu Y,Bai H,Chang YZ
PA5-85256 was used in Western Blotting to identify a previously unexplored effect for FtMt in the BBB and provide evidence that iron-mediated oxidative stress in BMVECs is an early cause of BMVECs damage and BBB breakdown in ischemic stroke.
Sun Jun 26 00:00:00 UTC 2022
N-(3',4'-dimethoxycinnamonyl) anthranilic acid alleviates severe acute pancreatitis by inhibiting intestinal barrier dysfunction and NF-κB activation.
Drug development research
Zhao Z,Lu L,Li W
PA5-85256 was used in Western Blotting to investigate the role of anthranilic acid active synthetic derivative, N-(3',4'-dimethoxycinnamonyl) anthranilic acid (3,4-DAA), in intestinal barrier dysfunction of SAP.
Sat May 01 00:00:00 UTC 2021
N-(3',4'-dimethoxycinnamonyl) anthranilic acid alleviates severe acute pancreatitis by inhibiting intestinal barrier dysfunction and NF-κB activation.
Drug development research
Zhao Z,Lu L,Li W
PA5-85256 was used in Western Blotting to investigate the role of anthranilic acid active synthetic derivative, N-(3',4'-dimethoxycinnamonyl) anthranilic acid (3,4-DAA), in intestinal barrier dysfunction of SAP.
Sat May 01 00:00:00 UTC 2021
Ursodeoxycholic Acid Treatment Restores Gut Microbiota and Alleviates Liver Inflammation in Non-Alcoholic Steatohepatitic Mouse Model.
Frontiers in pharmacology
Li H,Wang Q,Chen P,Zhou C,Zhang X,Chen L
PA5-85256 was used in Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to explore the dynamic changes of gut microbiota at the different stages of NAFLD and determine whether ursodeoxycholic acid (UDCA) could improve liver histopathological features of non-alcoholic steatohepatitis (NASH) mice induced by a high-fat high-cholesterol (HFHC) diet and its impact on gut microbiota.
Fri Dec 24 00:00:00 UTC 2021
Ursodeoxycholic Acid Treatment Restores Gut Microbiota and Alleviates Liver Inflammation in Non-Alcoholic Steatohepatitic Mouse Model.
Frontiers in pharmacology
Li H,Wang Q,Chen P,Zhou C,Zhang X,Chen L
PA5-85256 was used in Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to explore the dynamic changes of gut microbiota at the different stages of NAFLD and determine whether ursodeoxycholic acid (UDCA) could improve liver histopathological features of non-alcoholic steatohepatitis (NASH) mice induced by a high-fat high-cholesterol (HFHC) diet and its impact on gut microbiota.
Fri Dec 24 00:00:00 UTC 2021
Release of insulin produced by the choroid plexis is regulated by serotonergic signaling.
JCI insight
Mazucanti CH,Liu QR,Lang D,Huang N,O'Connell JF,Camandola S,Egan JM
PA5-85256 was used in Immunohistochemistry (PFA) to show for the first time to our knowledge that insulin is produced by EChP in the brain, and its release is modulated at least by serotonin but not glucose.
Thu Dec 05 00:00:00 UTC 2019
