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ZP4 Antibody (PA5-101974) in IHC (P)
Immunohistochemistry analysis of ZP4 in human kidney cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with ZP4 polyclonal antibody (Product # PA5-101974) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-101974
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ZP4(Accession Q12836), corresponding to amino acid residues A231-L281.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2851406
产品详细信息
Antibody detects endogenous levels of total ZP4.
靶标信息
The mammalian zona pellucida is composed of four major glycoproteins, ZP1, ZP2, ZP3 and ZP4, which may act as sperm receptors. Two forms of porcine ZP4 peptides exist: one consisting of 128 amino acid residues and the other of 133 amino acid residues. These two peptides are identical, except the larger form contains an additional five amino acid sequence at its carboxy-terminal end. Both peptides have two potential N-linked glycosylation sites. The smaller peptide shares 39.1% identity with the amino-terminal region of mouse ZP2 polypeptide. Based on results from animal studies, ZP4 antigen is a promising candidate for the development of a contraceptive vaccine.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: zona pellucida 4; zona pellucida B glycoprotein; Zona pellucida glycoprotein 4; Zona pellucida protein B; Zona pellucida sperm-binding protein 4; Zp-4
基因别名: ZBP; Zp-4; ZP1; ZP4; ZPB
UniProt ID: (Human) Q12836
Entrez Gene ID: (Human) 57829, (Rat) 282833
positive regulation of humoral immune response
single fertilization
protein kinase A signaling
intracellular signal transduction
positive regulation of T cell proliferation
positive regulation of protein kinase activity
acrosomal vesicle exocytosis
protein kinase C signaling
positive regulation of acrosome reaction
negative regulation of binding of sperm to zona pellucida
binding of sperm to zona pellucida
