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ZPK Antibody (PA5-100731) in IHC (P)
Immunohistochemistry analysis of ZPK in mouse kidney tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with ZPK polyclonal antibody (Product # PA5-100731) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-100731
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MAP3K12(Accession Q12852), corresponding to amino acid residues R8-P58.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2850234
产品详细信息
Antibody detects endogenous levels of total MAP3K12.
靶标信息
ZPK is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DLK; Dual leucine zipper bearing kinase; dual leucine zipper kinase; dual leucine zipper kinase DLK; leucine zipper protein kinase; Leucine-zipper protein kinase; M3KC; MAPK-upstream kinase; Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase); mitogen activated protein kinase kinase kinase 12; Mitogen-activated protein kinase kinase kinase 12; Mixed lineage kinase; MUK; protein kinase MUK; Zipper (leucine) protein kinase; ZPK
基因别名: DLK; MAP3K12; MEKK12; MUK; PK; ZPK; ZPKP1
UniProt ID: (Human) Q12852, (Rat) Q63796, (Mouse) Q60700
Entrez Gene ID: (Human) 7786, (Rat) 25579, (Mouse) 26404
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
protein kinase binding
protein homodimerization activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
activation of MAPKK activity
protein phosphorylation
JNK cascade
histone phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
intracellular signal transduction
protein autophosphorylation
mitophagy in response to mitochondrial depolarization
negative regulation of motor neuron apoptotic process
phosphorylation
