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alpha-1 Antitrypsin Antibody (PA5-118256) in WB
Western Blot using alpha-1 Antitrypsin Polyclonal Antibody (Product # PA5-118256) at 1:500 dilution. Lane A: Rat Liver tissue lysate, Lane B: Rat Spleen tissue lysate. Lysates/proteins at 30 μg per lane. Secondary antibody: Goat Anti-Rabbit IgG (H+L)/HRP at 1:10,000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 46 kDa. Observed band size: 54 kDa.
产品信息
PA5-118256
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Rat SerpinA1 Protein
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography, Protein A
保存液
PBS
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2902855
靶标信息
Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: a-1 AT; a1-antitrypsin; alpha 1 antitrypsin; Alpha-1-antiproteinase; Alpha-1-antitrypsin; alpha-1-antitrypsin (protease inhibitor); alpha-1-protease inhibitor; Alpha-1-proteinase inhibitor; Digestive Zymogen; MGC23330; MGC9222; Protease Serine 1; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1; Serine Protease 1; serine protease inhibitor alpha 1; Serpin A1; TRP1; TRY1
基因别名: AAT; Pi; Serpina1; Spi1
UniProt ID: (Rat) P17475
Entrez Gene ID: (Rat) 24648
response to hypoxia
acute-phase response
inflammatory response
response to inorganic substance
response to lead ion
response to organic cyclic compound
response to estradiol
response to lipopolysaccharide
response to methanol
response to triglyceride
response to cytokine
response to chromate
negative regulation of serine-type endopeptidase activity
