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Alomone Labs, LTD
alpha 1D-Adrenergic Receptor (extracellular) Polyclonal Antibody
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alpha 1D-Adrenergic Receptor (extracellular) Antibody (AAR-019-200UL) in ICC/IF
Expression of alpha 1D-Adrenoceptorin rat PC12 cells - Cell surface detection of alpha 1D-Adrenoceptor in intact living rat pheochromocytoma PC12 cells. A. Extracellular staining of cells using Anti- alpha 1D-Adrenergic Receptor (extracellular) Antibody (#AAR-019) (1:100)followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody . B. Merge of A and live view of the cells.
产品信息
AAR-019-200UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)EPVPPDERF*SGITEE, corresponding to amino acid residues 231-245 of rat alpha 1D-adrenoceptor with replacement of cysteine 240 (C240) with serine (*S), 3rd extracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
靶标信息
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADA1D; adrenergic receptor delta1; adrenergic receptor, alpha 1d; adrenergic, alpha -1D-, receptor; adrenergic, alpha-1A-, receptor; adrenergic, alpha-1D-, receptor; alpha 1D-adrenoceptor; alpha 1D-adrenoreceptor; Alpha-1A adrenergic receptor; Alpha-1D adrenergic receptor; Alpha-1D adrenoceptor; Alpha-1D adrenoreceptor; alpha-1D-adrenergic receptor; Alpha-adrenergic receptor 1a; Alpha1delta-AR; RA42
基因别名: [a]1d; Adra-1; ADRA1; ADRA1A; ADRA1D; ADRA1R; Adrd1; ALPHA1; alpha1D-AR; DAR; dJ779E11.2; Gpcr8; Spr8
UniProt ID: (Human) P25100, (Rat) P23944
Entrez Gene ID: (Human) 146, (Mouse) 11550, (Rat) 29413
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
DNA metabolic process
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
multicellular organism development
cell proliferation
positive regulation of cell proliferation
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
adenylate cyclase-activating adrenergic receptor signaling pathway
negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure
signal transduction
aging
micturition
adrenergic receptor signaling pathway
